The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Comparative Study Pragmatic Clinical Trial
Volatile Anesthetics versus Total Intravenous Anesthesia for Cardiac Surgery.
Volatile (inhaled) anesthetic agents have cardioprotective effects, which might improve clinical outcomes in patients undergoing coronary-artery bypass grafting (CABG). ⋯ Among patients undergoing elective CABG, anesthesia with a volatile agent did not result in significantly fewer deaths at 1 year than total intravenous anesthesia. (Funded by the Italian Ministry of Health; MYRIAD ClinicalTrials.gov number, NCT02105610.).
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Letter Retraction Of Publication
Retraction: Steering CAR T Cells into Solid Tumors. N Engl J Med 2019;380:289-91.
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Multicenter Study Clinical Trial
Pregnancy-Adapted YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism.
Pulmonary embolism is one of the leading causes of maternal death in the Western world. Because of the low specificity and sensitivity of the d-dimer test, all pregnant women with suspected pulmonary embolism undergo computed tomographic (CT) pulmonary angiography or ventilation-perfusion scanning, both of which involve radiation exposure to the mother and fetus. Whether a pregnancy-adapted algorithm could be used to safely avoid diagnostic imaging in pregnant women with suspected pulmonary embolism is unknown. ⋯ Pulmonary embolism was safely ruled out by the pregnancy-adapted YEARS diagnostic algorithm across all trimesters of pregnancy. CT pulmonary angiography was avoided in 32 to 65% of patients. (Funded by Leiden University Medical Center and 17 other participating hospitals; Artemis Netherlands Trial Register number, NL5726.).