The New England journal of medicine
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Comment Letter
A Trial of M72/AS01E Vaccine to Prevent Tuberculosis. Reply.
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Randomized Controlled Trial Multicenter Study Comparative Study
Initial Invasive or Conservative Strategy for Stable Coronary Disease.
Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than in those who receive medical therapy alone is uncertain. ⋯ Among patients with stable coronary disease and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of ischemic cardiovascular events or death from any cause over a median of 3.2 years. The trial findings were sensitive to the definition of myocardial infarction that was used. (Funded by the National Heart, Lung, and Blood Institute and others; ISCHEMIA ClinicalTrials.gov number, NCT01471522.).