The New England journal of medicine
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Editorial Comment
Back to the Future - The Therapeutic Potential of Psychedelic Drugs.
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Randomized Controlled Trial Multicenter Study
Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure.
Patients with acute hypoxemic respiratory failure in the intensive care unit (ICU) are treated with supplemental oxygen, but the benefits and harms of different oxygenation targets are unclear. We hypothesized that using a lower target for partial pressure of arterial oxygen (Pao2) would result in lower mortality than using a higher target. ⋯ Among adult patients with acute hypoxemic respiratory failure in the ICU, a lower oxygenation target did not result in lower mortality than a higher target at 90 days. (Funded by the Innovation Fund Denmark and others; HOT-ICU ClinicalTrials.gov number, NCT03174002.).