The New England journal of medicine
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Randomized Controlled Trial Comparative Study
Trial of Psilocybin versus Escitalopram for Depression.
Psilocybin may have antidepressant properties, but direct comparisons between psilocybin and established treatments for depression are lacking. ⋯ On the basis of the change in depression scores on the QIDS-SR-16 at week 6, this trial did not show a significant difference in antidepressant effects between psilocybin and escitalopram in a selected group of patients. Secondary outcomes generally favored psilocybin over escitalopram, but the analyses of these outcomes lacked correction for multiple comparisons. Larger and longer trials are required to compare psilocybin with established antidepressants. (Funded by the Alexander Mosley Charitable Trust and Imperial College London's Centre for Psychedelic Research; ClinicalTrials.gov number, NCT03429075.).