The New England journal of medicine
-
Randomized Controlled Trial Multicenter Study
Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke.
Surgical occlusion of the left atrial appendage has been hypothesized to prevent ischemic stroke in patients with atrial fibrillation, but this has not been proved. The procedure can be performed during cardiac surgery undertaken for other reasons. ⋯ Among participants with atrial fibrillation who had undergone cardiac surgery, most of whom continued to receive ongoing antithrombotic therapy, the risk of ischemic stroke or systemic embolism was lower with concomitant left atrial appendage occlusion performed during the surgery than without it. (Funded by the Canadian Institutes of Health Research and others; LAAOS III ClinicalTrials.gov number, NCT01561651.).
-
Letter Case Reports
Rapid Sequencing-Based Diagnosis of Thiamine Metabolism Dysfunction Syndrome.
-
Randomized Controlled Trial Multicenter Study Comparative Study
Adjuvant Nivolumab versus Placebo in Muscle-Invasive Urothelial Carcinoma.
The role of adjuvant treatment in high-risk muscle-invasive urothelial carcinoma after radical surgery is not clear. ⋯ In this trial involving patients with high-risk muscle-invasive urothelial carcinoma who had undergone radical surgery, disease-free survival was longer with adjuvant nivolumab than with placebo in the intention-to-treat population and among patients with a PD-L1 expression level of 1% or more. (Funded by Bristol Myers Squibb and Ono Pharmaceutical; CheckMate 274 ClinicalTrials.gov number, NCT02632409.).
-
Editorial Comment
The Closing Argument for Surgical Left Atrial Appendage Occlusion.