The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Pragmatic Clinical Trial
Dexamethasone and Surgical-Site Infection.
The glucocorticoid dexamethasone prevents nausea and vomiting after surgery, but there is concern that it may increase the risk of surgical-site infection. ⋯ Dexamethasone was noninferior to placebo with respect to the incidence of surgical-site infection within 30 days after nonurgent, noncardiac surgery. (Funded by the Australian National Health and Medical Research Council and others; PADDI Australian New Zealand Clinical Trials Registry number, ACTRN12614001226695.).
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Randomized Controlled Trial Multicenter Study Comparative Study
Four-Month Rifapentine Regimens with or without Moxifloxacin for Tuberculosis.
Rifapentine-based regimens have potent antimycobacterial activity that may allow for a shorter course in patients with drug-susceptible pulmonary tuberculosis. ⋯ The efficacy of a 4-month rifapentine-based regimen containing moxifloxacin was noninferior to the standard 6-month regimen in the treatment of tuberculosis. (Funded by the Centers for Disease Control and Prevention and others; Study 31/A5349 ClinicalTrials.gov number, NCT02410772.).
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Randomized Controlled Trial
Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined.
Weight regain after weight loss is a major problem in the treatment of persons with obesity. ⋯ A strategy combining exercise and liraglutide therapy improved healthy weight loss maintenance more than either treatment alone. (Funded by the Novo Nordisk Foundation and others; EudraCT number, 2015-005585-32; ClinicalTrials.gov number, NCT04122716.).