The New England journal of medicine
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Randomized Controlled Trial
A Randomized Trial of Enteral Glutamine for Treatment of Burn Injuries.
Glutamine is thought to have beneficial effects on the metabolic and stress response to severe injury. Clinical trials involving patients with burns and other critically ill patients have shown conflicting results regarding the benefits and risks of glutamine supplementation. ⋯ In patients with severe burns, supplemental glutamine did not reduce the time to discharge alive from the hospital. (Funded by the U.S. Department of Defense and the Canadian Institutes of Health Research; RE-ENERGIZE ClinicalTrials.gov number, NCT00985205.).
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Randomized Controlled Trial Multicenter Study
Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis.
Early aggressive hydration is widely recommended for the management of acute pancreatitis, but evidence for this practice is limited. ⋯ In this randomized trial involving patients with acute pancreatitis, early aggressive fluid resuscitation resulted in a higher incidence of fluid overload without improvement in clinical outcomes. (Funded by Instituto de Salud Carlos III and others; WATERFALL ClinicalTrials.gov number, NCT04381169.).