The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Comparative Study
Decolonization in Nursing Homes to Prevent Infection and Hospitalization.
Nursing home residents are at high risk for infection, hospitalization, and colonization with multidrug-resistant organisms. ⋯ In nursing homes, universal decolonization with chlorhexidine and nasal iodophor led to a significantly lower risk of transfer to a hospital due to infection than routine care. (Funded by the Agency for Healthcare Research and Quality; Protect ClinicalTrials.gov number, NCT03118232.).
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Randomized Controlled Trial Multicenter Study
Trial of Botulinum Toxin for Isolated or Essential Head Tremor.
Local injections of botulinum toxin type A have been used to treat essential head tremor but have not been extensively studied in randomized trials. ⋯ Injection of botulinum toxin into each splenius capitis muscle on day 0 and during week 12 was more effective than placebo in reducing the severity of isolated or essential head tremor at 18 weeks but not at 24 weeks, when the effects of injection might be expected to wane, and was associated with adverse events. (Funded by the French Ministry of Health; Btx-HT ClinicalTrials.gov number, NCT02555982.).
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Randomized Controlled Trial Comparative Study
Nivolumab plus Gemcitabine-Cisplatin in Advanced Urothelial Carcinoma.
No new agent has improved overall survival in patients with unresectable or metastatic urothelial carcinoma when added to first-line cisplatin-based chemotherapy. ⋯ Combination therapy with nivolumab plus gemcitabine-cisplatin resulted in significantly better outcomes in patients with previously untreated advanced urothelial carcinoma than gemcitabine-cisplatin alone. (Funded by Bristol Myers Squibb and Ono Pharmaceutical; CheckMate 901 ClinicalTrials.gov number, NCT03036098.).