The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Comparative Study
Perioperative Chemotherapy or Preoperative Chemoradiotherapy in Esophageal Cancer.
The best multimodal approach for resectable locally advanced esophageal adenocarcinoma is unclear. An important question is whether perioperative chemotherapy is preferable to preoperative chemoradiotherapy. ⋯ Perioperative chemotherapy with FLOT led to improved survival among patients with resectable esophageal adenocarcinoma as compared with preoperative chemoradiotherapy. (Funded by the German Research Foundation; ESOPEC ClinicalTrials.gov number, NCT02509286.).