International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · May 2005
PSA doubling time kinetics during prostate cancer biochemical relapse after external beam radiation therapy.
To investigate whether prostate-specific antigen PSA doubling time (PSADT) is constant in men with biochemical prostate cancer relapse after external beam radiotherapy (EBRT). ⋯ PSA initially rises more rapidly after AA cessation, probably because of testosterone recovery. A subgroup of patients, who received secondary intervention after treatment with radiotherapy alone, showed a change in PSADT, to a faster velocity. This greater than constant exponential PSA growth is presumably the catalyst for secondary intervention. Otherwise, PSADT did not change during prostate cancer biochemical relapse.
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Int. J. Radiat. Oncol. Biol. Phys. · May 2005
Patient subsets with T1-T2, node-negative breast cancer at high locoregional recurrence risk after mastectomy.
To identify patient subsets with T1-T2N0 breast cancer at high risk of locoregional recurrence (LRR) who may warrant consideration for postmastectomy radiotherapy. ⋯ Women with pT1-T2N0 breast cancer experienced a LRR risk of approximately 20% in the presence of Grade 3 disease with LVI or Grade 3 disease, T2 tumors, and no systemic therapy. These subsets of node-negative patients warrant consideration of for postmastectomy radiotherapy.
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Int. J. Radiat. Oncol. Biol. Phys. · May 2005
Clinical TrialPhase II study of radiotherapy with three-dimensional conformal boost concurrent with paclitaxel and cisplatin for Stage IIIB non-small-cell lung cancer.
To evaluate the efficacy and toxicity of concurrent chemoradiotherapy with paclitaxel/cisplatin for Stage IIIB locally advanced non-small-cell lung cancer (NSCLC). ⋯ Three-dimensional conformal radiotherapy, combined with paclitaxel and cisplatin chemotherapy, was associated with a satisfactory outcome with manageable toxicity. Further investigations are needed to improve the local control.
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Int. J. Radiat. Oncol. Biol. Phys. · May 2005
Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapy.
After radiotherapy (RT), children with diffuse intrinsic pontine gliomas (DIPG) are followed with sequential magnetic resonance imaging (MRI). However, MRI changes do not necessarily reflect tumor progression, and therefore additional noninvasive tools are needed to improve the definition of progression vs. treatment-related changes. In this study, we determined the feasibility and accuracy of multivoxel proton magnetic resonance spectroscopic imaging (1H-MRSI) for monitoring pediatric patients with DIPG. ⋯ Multivoxel MRSI is a feasible and reproducible noninvasive tool for assessing pediatric DIPG. Longitudinal multivoxel MRSI measurements have potential value in assessing response to radiation or other therapies, because they offer more coverage than single-voxel techniques and provide reliable spectral data.
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Int. J. Radiat. Oncol. Biol. Phys. · May 2005
Where to locate the isocenter? The treatment strategy for repeat trigeminal neuralgia radiosurgery.
The purpose of this study is to investigate how the spatial relationship between the isocenters of the first and second radiosurgeries affects the overall outcome. ⋯ Image registration between MR scans of the first and second radiosurgeries helps target delineation and radiosurgery treatment planning. Increasing the isocenter distance between the two radiosurgeries treated a longer segment of the trigeminal neuralgia nerve and was associated with a trend toward improved pain relief.