International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · Aug 2008
Comparative StudyDosimetric comparison of bone marrow-sparing intensity-modulated radiotherapy versus conventional techniques for treatment of cervical cancer.
To compare bone marrow-sparing intensity-modulated pelvic radiotherapy (BMS-IMRT) with conventional (four-field box and anteroposterior-posteroanterior [AP-PA]) techniques in the treatment of cervical cancer. ⋯ BMS-IMRT reduced irradiation of PBM compared with the four-field box technique. Compared with the AP-PA technique, BMS-IMRT reduced lumbosacral spine bone marrow irradiation and reduced the volume of PBM irradiated to high doses. Therefore BMS-IMRT might reduce acute hematologic toxicity compared with conventional techniques.
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Int. J. Radiat. Oncol. Biol. Phys. · Aug 2008
Randomized Controlled Trial Comparative StudyPreliminary results of a prospective randomized trial comparing concurrent chemoradiotherapy plus adjuvant chemotherapy with radiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma in endemic regions of china.
A prospective randomized trial was performed to evaluate the efficacy of concurrent chemotherapy and adjuvant chemotherapy in patients with locoregionally advanced nasopharyngeal carcinoma (NPC) in endemic regions of China. ⋯ This trial demonstrated the significant survival benefits of concurrent chemotherapy plus adjuvant chemotherapy in patients with locoregionally advanced NPC in endemic regions of China.
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Int. J. Radiat. Oncol. Biol. Phys. · Aug 2008
ReviewImpact of drug therapy, radiation dose, and dose rate on renal toxicity following bone marrow transplantation.
To demonstrate a radiation dose response and to determine the dosimetric and chemotherapeutic factors that influence the incidence of late renal toxicity following total body irradiation (TBI). ⋯ A dose response for renal damage after TBI was identified. Fractionation and low dose rates are factors to consider when delivering TBI to patients undergoing bone marrow transplantation. Drug therapy also has a major impact on kidney function and can modify the dose-response function.
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Int. J. Radiat. Oncol. Biol. Phys. · Aug 2008
Multicenter StudyResults of hematopoietic stem cell transplantation after treatment with different high-dose total-body irradiation regimens in five Dutch centers.
To evaluate results of high-dose total-body irradiation (TBI) regimens for hematopoietic stem cell transplantation. ⋯ Both RI and NRM were significantly influenced by the size of the BED of single-dose or two-fraction TBI regimens; OS and RFS were not. Age was of highly significant influence on NRM, but there was no influence of age on RI. Hyperfractionated TBI with a high BED might be useful, assuming NRM can be reduced.
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Int. J. Radiat. Oncol. Biol. Phys. · Aug 2008
Effect of high-dose-rate 192Ir source activity on late rectal bleeding after intracavitary radiation therapy for uterine cervix cancer.
This retrospective study analyzed the effect of the activity of high-dose-rate (HDR) (192)Ir source on late rectal bleeding after HDR intracavitary radiotherapy (ICRT) in patients with uterine cervix cancer. ⋯ This is the first clinical report concerning the source activity effect of HDR (192)Ir on late rectal bleeding in patients undergoing HDR-ICRT. This suggests that when source activity is higher than 2.4 cGy.m(2).h(-1), ICRT should be performed with more caution not to exceed 100 Gy(3) in total.