International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · Jun 2009
Frameless stereotactic body radiotherapy for lung cancer using four-dimensional cone beam CT guidance.
To quantify the localization accuracy and intrafraction stability of lung cancer patients treated with frameless, four-dimensional (4D) cone beam computed tomography (CBCT)-guided stereotactic body radiotherapy (SBRT) and to calculate and validate planning target volume (PTV) margins to account for the residual geometric uncertainties. ⋯ Frameless SBRT can be safely administered using 4D-CBCT guidance. Even with considerable breathing motion, the PTV margins can safely be kept small, allowing patients with larger tumors to benefit from the advantages of SBRT. In case bony anatomy would be used as a surrogate for tumor position, considerably larger PTV margins would be required.
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Int. J. Radiat. Oncol. Biol. Phys. · Jun 2009
Comparative StudyPlanning the breast boost: comparison of three techniques and evolution of tumor bed during treatment.
To evaluate the accuracy of two clinical techniques for electron boost planning compared with computed tomography (CT)-based planning. Additionally, we evaluated the tumor bed characteristics at whole breast planning and boost planning. ⋯ The results of our study have shown that CT-based planning allows for optimal tumor bed coverage compared with clinical and scar-based approaches. However, in the setting of a poorly visualized cavity on CT without surgical clips, palpation/clinical-based planning can help delineate the appropriate target volumes and is superior to scar-based planning. CT simulation at boost planning could allow for a reduction in the boost volumes.
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Int. J. Radiat. Oncol. Biol. Phys. · Jun 2009
Volumetric modulated arc radiotherapy for vestibular schwannomas.
To evaluate volumetric modulated arc radiotherapy (RapidArc [RA]), a novel approach allowing for rapid treatment delivery, for the treatment of vestibular schwannoma (VS). ⋯ The RA plans consistently achieved a higher CI and decrease in areas of low-dose irradiation. This, together with shorter treatment delivery times, has led to RA replacing our conventional five-arc radiosurgery technique for VS.
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Int. J. Radiat. Oncol. Biol. Phys. · Jun 2009
Long-term experience with World Health Organization grade III (malignant) meningiomas at a single institution.
To evaluate the outcomes for patients with Grade III meningiomas as defined by the 2007 World Health Organization standards. ⋯ This is one of the few studies reporting the outcomes for malignant meningioma patients according to recent definitions. Our results are consistent with existing reports of the overall poor outcomes for atypical and malignant meningioma patients. From the available data, surgical resection followed by RT and salvage therapy can lead to extended survival.
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Int. J. Radiat. Oncol. Biol. Phys. · Jun 2009
Randomized Controlled Trial Multicenter StudyRecognizing false biochemical failure calls after radiation with or without neo-adjuvant androgen deprivation for prostate cancer.
We studied prostate-specific antigen (PSA) changes after radiation with or without neoadjuvant androgen deprivation to determine posttreatment PSA scenarios in which false-positive biochemical failures (FPBF) are most likely to occur. ⋯ The Phoenix definition avoided 50% of FPBF calls that occurred with the ASTRO definition. Failures should be confirmed by further PSA rises before investigation and treatment is considered.