International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · Aug 2012
Multicenter StudyA multi-institutional study of feasibility, implementation, and early clinical results with noninvasive breast brachytherapy for tumor bed boost.
To evaluate the feasibility, implementation, and early results of noninvasive breast brachytherapy (NIBB) for tumor bed boost with whole breast radiation therapy (WBRT). ⋯ These data indicate that NIBB is feasible and can be consistently implemented in a broad array of practice settings. Preliminary evaluation suggests that NIBB is associated with acceptably mild normal tissue toxicity and favorable early cosmesis. The application of NIBB before WBRT may be associated with better patient tolerance at the expense of less favorable cosmetic outcome.
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Int. J. Radiat. Oncol. Biol. Phys. · Aug 2012
Subclassification of recursive partitioning analysis Class II patients with brain metastases treated radiosurgically.
Although the recursive partitioning analysis (RPA) class is generally used for predicting survival periods of patients with brain metastases (METs), the majority of such patients are Class II and clinical factors vary quite widely within this category. This prompted us to divide RPA Class II patients into three subclasses. ⋯ Our new grading system should be considered when designing future clinical trials involving brain MET patients.
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Int. J. Radiat. Oncol. Biol. Phys. · Aug 2012
Comparative StudySimilar survival with breast conservation therapy or mastectomy in the management of young women with early-stage breast cancer.
To evaluate survival outcomes of young women with early-stage breast cancer treated with breast conservation therapy (BCT) or mastectomy, using a large, population-based database. ⋯ Our analysis of this population-based database suggests that young women with early-stage breast cancer have similar survival rates whether treated with BCT or mastectomy. These patients should be counseled appropriately regarding their treatment options and should not choose a mastectomy based on the assumption of improved survival.
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Int. J. Radiat. Oncol. Biol. Phys. · Aug 2012
Immortal time bias: a frequently unrecognized threat to validity in the evaluation of postoperative radiotherapy.
To evaluate the influence of immortal time bias on observational cohort studies of postoperative radiotherapy (PORT) and the effectiveness of sequential landmark analysis to account for this bias. ⋯ Although the majority of previous SEER articles do not correct for it, immortal time bias leads to altered estimates of PORT effectiveness, which are very sensitive to landmark selection. We suggest the routine use of sequential landmark analysis to account for this bias.
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Int. J. Radiat. Oncol. Biol. Phys. · Aug 2012
Comparative StudyCritical appraisal of Acuros XB and Anisotropic Analytic Algorithm dose calculation in advanced non-small-cell lung cancer treatments.
To assess the clinical impact of the Acuros XB algorithm (implemented in the Varian Eclipse treatment-planning system) in non-small-cell lung cancer (NSCLC) cases. ⋯ The availability of Acuros XB could improve patient dose estimation, increasing the data consistency of clinical trials.