International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · Sep 2010
A population-based study of subsequent primary malignancies after endometrial cancer: genetic, environmental, and treatment-related associations.
To examine the risk of subsequent primary malignancies (SPMs) in women diagnosed with endometrial cancer. ⋯ Genetic, environmental, and treatment-related factors influence SPM risk. Genetic factors may contribute to the increased risk of colorectal cancer. Smoking's negative effect on endometrial cancer risk factors might explain the decreased risk of lung and oropharyngeal cancer. Patients treated with radiotherapy likely have a small but significantly increased risk of bladder, vagina, colon, and soft-tissue SPM.
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Int. J. Radiat. Oncol. Biol. Phys. · Sep 2010
Hypofractionated boost to the dominant tumor region with intensity modulated stereotactic radiotherapy for prostate cancer: a sequential dose escalation pilot study.
To evaluate the feasibility, tolerability, and preliminary outcomes in patients with prostate cancer treated according to a hypofractionated dose escalation protocol to boost the dominant tumor-bearing region of the prostate. ⋯ Intensity-modulated radiotherapy hypofractionated boost dose escalation under stereotactic conditions was feasible, and showed excellent outcomes with acceptable long-term toxicity. This approach may well be considered an alternative to high-dose-rate brachytherapy.
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Int. J. Radiat. Oncol. Biol. Phys. · Sep 2010
Comment LetterThe rate of secondary malignancies after radical prostatectomy versus external beam radiation therapy for localized prostate cancer: a population-based study on 17,845 patients. In regard to Bhojani et al. (Int J Radiat Oncol Biol Phys 2010;76:342-348.).
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Int. J. Radiat. Oncol. Biol. Phys. · Aug 2010
Effect of carbon ion radiotherapy for sacral chordoma: results of Phase I-II and Phase II clinical trials.
To summarize the results of treatment for sacral chordoma in Phase I-II and Phase II carbon ion radiotherapy trials for bone and soft-tissue sarcomas. ⋯ Carbon ion radiotherapy appears effective and safe in the treatment of patients with sacral chordoma and offers a promising alternative to surgery.
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Int. J. Radiat. Oncol. Biol. Phys. · Aug 2010
The impact of acute urinary retention after iodine-125 prostate brachytherapy on health-related quality of life.
To evaluate the impact of acute urinary retention (AUR) in patients treated with (125)I prostate brachytherapy on short- and long-term health-related quality of life (HRQOL); and to assess whether pretreatment HRQOL has additional value in the prediction of AUR. ⋯ Acute urinary retention after prostate brachytherapy has a significant negative impact on patient's HRQOL up to 6 years after treatment, in terms of both global QOL measures and urinary symptom scores. Furthermore, our results suggest limited value of pretreatment HRQOL measures for the prediction of AUR.