International journal of radiation oncology, biology, physics
-
Int. J. Radiat. Oncol. Biol. Phys. · Mar 2008
Multicenter Study Clinical TrialMulti-institution prospective trial of reduced-dose craniospinal irradiation (23.4 Gy) followed by conformal posterior fossa (36 Gy) and primary site irradiation (55.8 Gy) and dose-intensive chemotherapy for average-risk medulloblastoma.
Limiting the neurocognitive sequelae of radiotherapy (RT) has been an objective in the treatment of medulloblastoma. Conformal RT to less than the entire posterior fossa (PF) after craniospinal irradiation might reduce neurocognitive sequelae and requires evaluation. ⋯ This prospective trial has demonstrated that irradiation of less than the entire PF after 23.4 Gy craniospinal irradiation for average-risk medulloblastoma results in disease control comparable to that after treatment of the entire PF.
-
Int. J. Radiat. Oncol. Biol. Phys. · Mar 2008
The growth of radiation oncology in mainland China during the last 10 years.
This study aimed to investigate the growth of radiation oncology in mainland China during the last 10 years. ⋯ Radiation oncology has grown remarkably, and advanced techniques have been implemented very quickly in mainland China during last 10 years, but resources are still far less than the recommendation of the World Health Organization for the population.
-
Int. J. Radiat. Oncol. Biol. Phys. · Mar 2008
Estimate of radiobiologic parameters from clinical data for biologically based treatment planning for liver irradiation.
The Radiation Therapy Oncology Group (RTOG) is initiating a few new hypofractionation regimens (RTOG 0438) to treat liver cancer patients. To evaluate the radiobiologic equivalence between different regimens requires reliable radiobiologic parameters. The purpose of this work is to estimate a plausible set of such parameters for liver tumors and to design new optimized dose fractionation schemes to increase patient survival. ⋯ A plausible set of radiobiologic parameters has been obtained based on clinical data. These parameters may be used for radiation treatment planning of liver tumors, in particular, for the design of new treatment regimens aimed at dose escalation.
-
Int. J. Radiat. Oncol. Biol. Phys. · Mar 2008
Excellent local control rates and distinctive patterns of failure in myxoid liposarcoma treated with conservation surgery and radiotherapy.
To evaluate the local control rates and patterns of metastatic relapse in patients with localized myxoid liposarcoma treated with conservation surgery and radiotherapy (RT). ⋯ The results of our study have shown that RT and conservation surgery for localized myxoid liposarcoma provide excellent local control. Distant metastatic relapse tended to occur in the retroperitoneum and other nonpulmonary soft tissues. Therefore, staging and surveillance imaging should include the abdomen and pelvis, as well as the thorax, for patients with localized myxoid liposarcoma.
-
Int. J. Radiat. Oncol. Biol. Phys. · Feb 2008
Long-term clinical and functional outcomes after treatment for localized Ewing's tumor of the lower extremity.
Retrospective review describing the 35-year University of Florida experience with Ewing's tumors of the lower extremity. ⋯ Overall survival and CSS were not statistically compromised, but we observed an increased risk of relapse and local failure in patients treated with RT alone, thereby justifying a transition toward primary surgical management in suitable patients. However, despite an adverse risk profile, patients treated with RT alone had similar long-term amputation-free survival and demonstrated comparable functional outcomes. Poor results observed in Ewing's of the femur mandate innovative surgical and RT strategies.