International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · Mar 2006
Cluster model analysis of late rectal bleeding after IMRT of prostate cancer: a case-control study.
Cluster models are newly developed normal-tissue complication probability models in which the spatial aspects of radiation-induced injury are taken into account by considering the size of spatially contiguous aggregates of damaged tissue units. The purpose of this study was to test the validity of a two-dimensional cluster model of late rectal toxicity based on maximum cluster size of damage to rectal surface. ⋯ This study suggests that a cluster model based on maximum cluster size of damage to rectal surface successfully incorporates spatial information beyond that contained in the rectal dose-surface histogram and may therefore provide a useful new tool for predicting rectal normal-tissue complication probability after radiotherapy.
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Int. J. Radiat. Oncol. Biol. Phys. · Mar 2006
Stereotactic linac-based radiosurgery in the treatment of cerebral arteriovenous malformations located deep, involving corpus callosum, motor cortex, or brainstem.
To evaluate patient outcome and obliteration rates after radiosurgery (RS) for cerebral arteriovenous malformations (AVM) located deep, in the motor cortex or brainstem and those involving corpus callosum. ⋯ Surgically inaccessible AVM can be successfully treated using RS with acceptable obliteration rates and low risk for late morbidity. The risk of intracranial hemorrhage is reduced after RS and depends on RS-based AVM score.
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Int. J. Radiat. Oncol. Biol. Phys. · Mar 2006
Low-grade toxicity after conformal radiation therapy for prostate cancer--impact of bladder volume.
To assess the impact of dose-volume histogram parameters on low-grade toxicity after radiotherapy for prostate cancer. ⋯ The patient's ability to fill the bladder has a major impact on the dose-volume histogram and both acute and late urinary toxicity.
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Int. J. Radiat. Oncol. Biol. Phys. · Mar 2006
Reproducibility of liver position using active breathing coordinator for liver cancer radiotherapy.
To measure the intrabreath-hold liver motion and the intrafraction and interfraction reproducibility of liver position relative to vertebral bodies using an active breathing coordinator (ABC) in patients with unresectable liver cancer treated with hypofractionated stereotactic body radiation therapy (SBRT). ⋯ Intrafraction reproducibility of liver position using ABC is good in the majority of screened patients. However, interfraction reproducibility is worse, suggesting a need for image guidance.
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Int. J. Radiat. Oncol. Biol. Phys. · Mar 2006
Intensity-modulated radiotherapy in high-grade gliomas: clinical and dosimetric results.
To report preliminary clinical and dosimetric data from intensity-modulated radiotherapy (IMRT) for malignant gliomas. ⋯ It is unlikely that IMRT will improve local control in high-grade gliomas without further dose escalation compared with conventional radiotherapy. However, it might result in decreased late toxicities associated with radiotherapy.