International journal of radiation oncology, biology, physics
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To evaluate erectile function after permanent prostate brachytherapy using a validated patient-administered questionnaire and to determine the effect of multiple clinical, treatment, and dosimetric parameters on penile erectile function. ⋯ Using a patient-administered validated quality-of-life instrument, brachytherapy-induced ED occurred in 50% of patients at 3 years. On multivariate analysis, preimplant erectile function and the D(50) to the proximal crura were the best predictors of brachytherapy-related erectile function. Because the proximal penis is the most significant treatment-related predictor of brachytherapy-related ED, techniques to minimize the radiation dose to the proximal penis may result in improved rates of potency preservation.
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Int. J. Radiat. Oncol. Biol. Phys. · Jun 2005
Benefit of respiration-gated stereotactic radiotherapy for stage I lung cancer: an analysis of 4DCT datasets.
High local control rates have been reported with stereotactic radiotherapy (SRT) for Stage I non-small-cell lung cancer. Because high-dose fractions are used, reduction in treatment portals will reduce the risk of toxicity to adjacent structures. Respiratory gating can allow reduced field sizes and planning four-dimensional computed tomography scans were retrospectively analyzed to study the benefits for gated SRT and identify patients who derive significant benefit from this approach. ⋯ The use of "standard population-based" margins for SRT leads to unnecessary normal tissue irradiation. The risk of toxicity is further reduced if respiration-gated radiotherapy is used to treat mobile tumors. These findings suggest that gated SRT will be of clinical relevance in selected patients with mobile tumors.
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Int. J. Radiat. Oncol. Biol. Phys. · Jun 2005
Anal canal carcinoma: early-stage tumors < or =10 mm (T1 or Tis): therapeutic options and original pattern of local failure after radiotherapy.
To investigate the clinical history, management, and pattern of recurrence of very early-stage anal canal cancer in a French retrospective survey. ⋯ Most recurrences occurred after a long disease-free interval after treatment and often outside the initial tumor site. These small anal cancers could be treated by RT using a small volume and moderate dose (40-50 Gy for subclinical lesions and 50-60 Gy for T1).
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Int. J. Radiat. Oncol. Biol. Phys. · Jun 2005
Treatment of pituitary adenomas by fractionated stereotactic radiotherapy: a prospective study of 110 patients.
To optimize and reduce the toxicity of pituitary adenoma irradiation by assessing the feasibility and effectiveness of fractionated stereotactic radiotherapy (FSR). ⋯ Surgery plus FSR is safe and effective. FSR focused to the target volume seems more suitable than standard radiotherapy, and standard fractionation reduces the risk of optic neuropathy sometimes observed after single-dose radiosurgery. Therefore, FSR allows us to consider combined transrhinoseptal surgery and early radiotherapy, with a curative goal without patient selection.
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Int. J. Radiat. Oncol. Biol. Phys. · Jun 2005
Long-term androgen deprivation increases Grade 2 and higher late morbidity in prostate cancer patients treated with three-dimensional conformal radiation therapy.
To determine whether the use of androgen deprivation (AD) increases late morbidity when combined with high-dose three-dimensional conformal radiation therapy (3D-CRT). ⋯ The use of LTAD seems to significantly increase the risk of both GU and GI morbidity for patients treated with 3D-CRT.