International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · Jun 1994
Clinical Trial Controlled Clinical TrialA phase I study of etanidazole and radiotherapy in malignant glioma.
To determine the maximum tolerable total dose (MTD) of etanidazole (ETA) when administered with external beam radiotherapy (XRT) and as a continuous infusion during stereotactic brachytherapy for patients with malignant glioma (anaplastic astrocytoma or glioblastoma multiforme or mixed cell tumors). ⋯ The clinical efficacy and radiation-related toxicity of these regimens are being evaluated. The doses of ETA that can be used with accelerated fractionation and with external beam irradiation plus brachytherapy have been established.
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Int. J. Radiat. Oncol. Biol. Phys. · Apr 1994
Uniform irradiation of the craniospinal axis with a penumbra modifier and an asymmetric collimator.
A technique is described that uses an independent, asymmetric collimator and a penumbra modifier to uniformly administer radiation over the craniospinal axis. ⋯ This single-field isocentric technique allows more uniform irradiation of the craniospinal axis than do previously described techniques.
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Int. J. Radiat. Oncol. Biol. Phys. · Mar 1994
Morbidity of ischemic heart disease in early breast cancer 15-20 years after adjuvant radiotherapy.
To assess the cardiac side effects, primarily the occurrence of ischemic heart disease in symptom-free patients with early breast cancer treated with radiotherapy. ⋯ Radiotherapy for left sided breast cancer with the mentioned treatment technique may present as an independent risk factor in the long-term development of ischemic heart disease, while left ventricular dysfunction could not be related to the previous irradiation. We emphasize the need to optimize adjuvant radiotherapy for early breast cancer by considering the dose both to the heart as well as the cancer.
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Int. J. Radiat. Oncol. Biol. Phys. · Mar 1994
Clinical TrialRectal complications in patients with carcinoma of the cervix treated with concomitant cisplatin and external beam irradiation with high dose rate brachytherapy: a dosimetric analysis.
This paper reports a dosimetric study of 43 patients treated with a combination of concomitant radiotherapy and chemotherapy (cisplatin) for locally advanced carcinoma of the cervix with the aim of investigating the correlation between the radiation dose to the rectum and the incidence of late rectal complications. ⋯ This investigation has revealed a significant correlation between the dose calculated at the rectal point defined by the ICRU and the incidence of late rectal complications in patients with carcinoma of the cervix undergoing concomitant radiotherapy and chemotherapy. Thus, this rectal reference point appears to be a useful prognostic indicator of late rectal complications in these patients and we recommend that the brachytherapy dose delivered to this rectal point be limited to the dose prescribed to point A for treatment regimens using three fractions of 8-10 Gy each, limiting the total dose to this point, including the external beam component, to 76 Gy. Further study will be required to determine whether this rule should be applied to patients receiving irradiation alone.
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Int. J. Radiat. Oncol. Biol. Phys. · Feb 1994
Comparative StudyComparison of continuous and pulsed low dose rate brachytherapy: biological equivalence in vivo.
Recent studies of human cell lines cultured in vitro and mathematical modeling of the response of acute and late responding tissues have predicted conditions for the equivalence in terms of cell killing of continuous and pulsed dose rate brachytherapy. The aim of this study was to test these predictions in vivo using an acutely responding normal tissue. ⋯ This in vivo study validates the prediction of biological equivalence between pulsed and continuous brachytherapy at a clinically relevant average dose rate and may generate further interest in this new treatment modality because of its advantages in radiation protection, dose optimization, and cost relative to standard low dose rate brachytherapy techniques.