Clinical neuropharmacology
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Clin Neuropharmacol · Nov 2009
Case ReportsRefractory metabolic acidosis as a complication of high-dose midazolam infusion for pediatric status epilepticus.
The use of midazolam for the treatment of status epilepticus in children has generally been shown to be well tolerated and safe. Furthermore, encouraging efficacy has been observed when pediatric patients with status epilepticus have received continuous intravenous infusions of midazolam. ⋯ Although this complication was observed in only 1 pediatric patient with cortical dysplasia, caution and close clinical and laboratory surveillance should be exercised when administering continuous intravenous infusions of midazolam to pediatric patients.