Intensive care medicine
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Intensive care medicine · Jan 1993
Clinical TrialHemodynamic effects of sodium bicarbonate in critically ill neonates.
To analyze the cardiovascular effects of sodium bicarbonate in neonates with metabolic acidosis. ⋯ Sodium bicarbonate in neonates with metabolic acidosis induces an increase in contractility and a reduction in afterload.
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Intensive care medicine · Jan 1993
Randomized Controlled Trial Comparative Study Clinical TrialAnticoagulant regimens in acute continuous hemodiafiltration: a comparative study.
To compare and contrast different heparin regimens for extracorporeal circuit anticoagulation in patients receiving acute continuous hemodiafiltration (ACHD). ⋯ Regional anticoagulation leads to longer filter survival than low dose heparin in shunt CAVHD. A regimen of no anticoagulation during femoral CAVHD leads to a filter life similar to that of low dose heparinization. During CVVHD, regional anticoagulation and low dose heparin are associated with similar filter survival times. In patients assessed to be at high risk of bleeding, treatment with CVVHD without anticoagulation results in adequate filter survival.
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Intensive care medicine · Jan 1993
Characterization of intensive care unit patients using a model based on the presence or absence of organ dysfunctions and/or infection: the ODIN model.
To evaluate the sensitivity, specificity and overall accuracy of a model based on the presence or absence of organ dysfunctions and/or infection (ODIN) to predict the outcome for intensive care unit patients. ⋯ These findings suggest that determination of the number and the type of organ dysfunctions and infection offers a clear and reliable method for characterizing ICU patients. Before a widespread use, this model requires to be validated in other institutions.
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Intensive care medicine · Jan 1993
Continuous veno-venous haemofiltration following cardio-pulmonary bypass. Indications and outcome in 35 patients.
To study the impact of continuous veno-venous haemofiltration on survival in patients with acute renal failure (ARF) following cardio-pulmonary bypass (CPB) surgery. ⋯ Despite the theoretical advantages of haemofiltration and the effective control of uraemia the mortality associated with ARF following CPB remains high and is probably determined by the number of failed organs systems.
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Intensive care medicine · Jan 1993
Clinical TrialAtracurium infusions in patients with fulminant hepatic failure awaiting liver transplantation.
To determine the pharmacokinetics and pharmacodynamics of the neuromuscular blocking agent atracurium besylate in patients with fulminant hepatic failure (FHF). ⋯ Atracurium kinetics and dynamics are near-normal even in patients with fulminant hepatic failure and renal failure; laudanosine accumulation will occur, but this is not associated with measurable central neurological effects. Implantation of a functioning liver graft results in clearance of laudanosine, which seems to be independent of renal function. Atracurium is an appropriate choice for producing neuromuscular blockade for periods of several days in patients with fulminant hepatic failure and renal impairment.