Intensive care medicine
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Intensive care medicine · Jul 2012
Isoflurane/nitrous oxide anesthesia and stress-induced procedures enhance neuroapoptosis in intrauterine growth-restricted piglets.
There is compelling evidence that interference of various anesthetics with synaptic functions and stress-provoking procedures during critical periods of brain maturation results in increased neuroapoptotic cell death. The hypothesis is that adverse intrauterine environmental conditions leading to intrauterine growth restriction (IUGR) with altered brain development may result in enhanced susceptibility to developmental anesthetic neurotoxicity. ⋯ There is no indication that the increased rate in neuroapoptosis in IUGR piglets is confounded by additional adverse systemic or organ-specific impairments resulting from administered mixed inhalation anesthesia. Developmental anesthetic and stress-induced neuroapoptosis presumably originated in response to fetal adaptations to adverse conditions during prenatal life and should be considered in clinical interventions on infants having suffered from fetal growth restriction.
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Intensive care medicine · Jul 2012
Letter Case ReportsMyocardial infarction due to malposition of ECMO cannula.
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Intensive care medicine · Jul 2012
Review Meta AnalysisSafety of gelatin for volume resuscitation--a systematic review and meta-analysis.
Gelatin is frequently used as a volume expander in critical care. Our goal was to investigate its safety. ⋯ Despite over 60 years of clinical practice, the safety and efficacy of gelatin cannot be reliably assessed in at least some settings in which it is currently used. We suggest the need to investigate and establish such safety.