Intensive care medicine
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Intensive care medicine · Jun 2015
Multicenter StudyVisualizing the pressure and time burden of intracranial hypertension in adult and paediatric traumatic brain injury.
To assess the impact of the duration and intensity of episodes of increased intracranial pressure on 6-month neurological outcome in adult and paediatric traumatic brain injury. ⋯ The intracranial pressure-time burden associated with worse outcome is visualised in a colour-coded plot. In children, secondary injury occurs at lower intracranial pressure thresholds as compared to adults. Impaired cerebrovascular autoregulation reduces the ability to tolerate intracranial pressure insults. Thus, 50 mmHg might be the lower acceptable threshold for cerebral perfusion pressure.
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Intensive care medicine · Jun 2015
Randomized Controlled TrialIntensive versus conventional glucose control in critically ill patients with traumatic brain injury: long-term follow-up of a subgroup of patients from the NICE-SUGAR study.
To compare the effect of intensive versus conventional blood glucose control in patients with traumatic brain injury. ⋯ Although patients with traumatic brain injury randomly assigned to intensive compared to conventional glucose control experienced moderate and severe hypoglycemia more frequently, we found no significant difference in clinically important outcomes.