Intensive care medicine
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Intensive care medicine · Jun 2020
ReviewAntimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper.
This Position Paper aims to review and discuss the available data on therapeutic drug monitoring (TDM) of antibacterials, antifungals and antivirals in critically ill adult patients in the intensive care unit (ICU). This Position Paper also provides a practical guide on how TDM can be applied in routine clinical practice to improve therapeutic outcomes in critically ill adult patients. ⋯ Although TDM should be the standard of care for most antimicrobials in every ICU, important barriers need to be addressed before routine TDM can be widely employed worldwide.
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Intensive care medicine · Jun 2020
Multicenter StudyHigh risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study.
Little evidence of increased thrombotic risk is available in COVID-19 patients. Our purpose was to assess thrombotic risk in severe forms of SARS-CoV-2 infection. ⋯ Despite anticoagulation, a high number of patients with ARDS secondary to COVID-19 developed life-threatening thrombotic complications. Higher anticoagulation targets than in usual critically ill patients should therefore probably be suggested.