Intensive care medicine
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Intensive care medicine · Apr 1998
Randomized Controlled Trial Clinical TrialIbuprofen does not impair renal function in patients undergoing infrarenal aortic surgery with epidural anaesthesia.
To investigate the effect of preoperative ibuprofen administration on renal function during and after infrarenal aortic surgery under thoracolumbar epidural anaesthesia (EPA). ⋯ The inhibition of endogenous prostaglandin release by ibuprofen does not substantially impair renal function during infrarenal aortic surgery under EPA.
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Intensive care medicine · Apr 1998
Randomized Controlled Trial Clinical TrialAcute normovolaemic haemodilution does not aggravate gastric mucosal acidosis during cardiac surgery.
Acute normovolaemic haemodilution with subsequent autologous blood transfusion after surgery is widely used to reduce homologous blood requirements during cardiac surgery. The hypothesis tested was whether a low intraoperative haematocrit (Hct) resulting from haemodilution decreases gastric mucosal pH (pHi). ⋯ Acute normovolaemic haemodilution does not aggravate gastric mucosal acidosis during cardiac surgery.
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Intensive care medicine · Mar 1998
Randomized Controlled Trial Clinical TrialThe effect of N-acetylcysteine on total serum anti-oxidant potential and urinary albumin excretion in critically ill patients.
To investigate the effects of N-acetylcysteine (NAC) when given as an early treatment to critically ill patients on the serum total anti-oxidant potential (TAP) and urine micro-albumin:creatinine (M:Cr) ratio. ⋯ Our results suggest that NAC had no significant effects on the progress of the TAP and the urinary albumin excretion in our patients, which may suggest that NAC at the given dose has no clinical relevance as an early treatment in the critically ill.
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Intensive care medicine · Feb 1998
Randomized Controlled Trial Clinical TrialEffects of human recombinant growth hormone (rhGH) on inflammatory responses in patients undergoing abdominal aortic aneurysm repair.
Human recombinant growth hormone (rhGH) has been shown to increase skeletal muscle protein synthesis and improve nitrogen balance in critically ill patients and those undergoing surgery. rhGH effects on hepatic protein turnover in critically ill patients are less clearly understood. ⋯ These results indicate that pre-operative administration of rhGH does not alter acute phase protein or inflammatory cytokine release in response to major surgery.
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Intensive care medicine · Jan 1998
Randomized Controlled Trial Clinical Trial Retracted PublicationVolume therapy in the critically ill: is there a difference?
There are still several concerns about the extensive and prolonged use of hydroxyethylstarch solution (HES) in critically ill patients. The effects of volume replacement with HES over 5 days on hemodynamics, laboratory data, and organ function were compared with volume therapy using human albumin (HA). ⋯ Volume therapy with 10% HES for 5 days in the ICU patient showed no disadvantages compared with an infusion regimen using 20% albumin. Volume replacement using HES may even be associated with improved hemodynamics. HES appears to be a valuable and significantly cheaper alternative to albumin--even for prolonged volume therapy in the critically ill patient.