Intensive care medicine
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Intensive care medicine · May 2007
Emergency feasibility in medical intensive care unit of extracorporeal life support for refractory cardiac arrest.
To report the feasibility, complications, and outcomes of emergency extracorporeal life support (ECLS) in refractory cardiac arrests in medical intensive care unit (ICU). ⋯ Emergency ECLS is feasible in medical ICU and should be considered as a resuscitative tool for selected patients suffering from refractory cardiac arrest.
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Intensive care medicine · May 2007
Retracted PublicationGlycogen synthase kinase-3beta inhibition attenuates the development of ischaemia/reperfusion injury of the gut.
This study investigated the effects of TDZD-8, a potent and selective GSK-3beta inhibitor, on tissue injury caused by ischaemia/reperfusion (I/R) of the gut. ⋯ Based on these findings we propose that TDZD-8 would be useful in the treatment of various ischaemia and reperfusion diseases.
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Intensive care medicine · Apr 2007
Ultra-rapid management of oral anticoagulant therapy-related surgical intracranial hemorrhage.
Intracranial hemorrhage in patients receiving oral anticoagulant (OAC) therapy is associated with poor neurological outcome. Prothrombin complex concentrate (PCC) is the gold-standard therapy to normalize hemostasis but remains underused. Ultra-rapid reversal of anticoagulation could reduce the time to biological and surgical hemostasis, and might improve outcome. We report the use of bolus infusions of PCC to immediately reverse anticoagulation and allow for urgent neurosurgical care. ⋯ A bolus infusion of PCC completely reverses anticoagulation within 3 min. Neurosurgery can be performed immediately in OAC-related intracranial hemorrhage. This study shows that OAC-treated patients can be managed as rapidly as non-anticoagulated patients.