Clinical therapeutics
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Clinical therapeutics · Jan 1983
Clinical TrialA premarketing multicenter trial of lorazepam injection.
Before the introduction of lorazepam injection to the Canadian market, its usefulness and acceptability were assessed in an open multicenter study. Anesthesiologists in teaching hospitals across the country were asked to substitute lorazepam injection for their usual anxiolytic premedicant in ten patients and to complete a brief case report on each patient. ⋯ The adverse effect most often reported, accounting for 84% of the drug-related adverse reactions, was postoperative drowsiness, which highlighted the need to administer the drug at least two hours before surgery. The anesthesiologists found lorazepam injection to be a satisfactory premedicant, rating it excellent to good in 73% of the patients treated.
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Clinical therapeutics · Jan 1983
Clinical TrialClinical trial of bacampicillin in acute bacterial infections.
A clinical trial of bacampicillin was carried out in 20 patients. The antibiotic was found to be effective in acute lobar pneumonia, pyogenic meningitis, acute and chronic bronchitis, acute pharyngitis, acute tonsillitis, cellulitis, furunculosis, and pyomyositis caused by such ampicillin-sensitive organisms as Neisseria meningitidis, Diplococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Streptococcus pyogenes, Klebsiella pneumoniae, and Escherichia coli. Rash in three patients was the only side effect encountered. It is concluded that while bacampicillin may have overcome some of the disadvantages of ampicillin, it retains its main attributes and some shortcomings.
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Studies among a total of about 300 patients with congestive heart failure treated over eight to ten months reveal a distinct and sustained benefit from vasodilator therapy. Increased longevity has not yet been established, but in most circumstances there has been noticeable symptomatic, radiological, and hemodynamic improvement. Unresolved problems continue to center around variability in response, difficulties in objective assessment (invasive and noninvasive) before and during therapy, and selection criteria for patients and drugs. Lesser problems include the construction of effective dosage schedules, deleterious effects after sudden withdrawal, development of tolerance, and side effects.
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Clinical therapeutics · Jan 1981
Comparative Study Clinical TrialKetamine fro postoperative analgesia after upper abdominal surgery.