The Journal of clinical psychiatry
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Review Meta Analysis
Repetitive transcranial magnetic stimulation for negative symptoms of schizophrenia: review and meta-analysis.
Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a treatment for the negative symptoms of schizophrenia. During the past decade, several trials have reported on the efficacy of rTMS treatment; however, the results were inconsistent. ⋯ The results of this meta-analysis warrant further study of rTMS as a potential treatment of negative symptoms of schizophrenia.
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Review Meta Analysis
Effects of lithium on cognitive performance: a meta-analysis.
Cognitive impairment is underrecognized among patients with bipolar disorder and may represent not only effects of the illness but also adverse effects of its treatments. Among these, lithium is the best-studied mood stabilizer. As its cognitive effects are mixed and not well-known, we assessed reported effects of lithium on cognitive performance. ⋯ Lithium treatment appears to have only few and minor negative effects on cognition.
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Meta Analysis Comparative Study
The acute efficacy of aripiprazole across the symptom spectrum of schizophrenia: a pooled post hoc analysis from 5 short-term studies.
To evaluate the efficacy of aripiprazole across a range of symptoms-positive, negative, disorganized thought, depression/anxiety, and hostility-in schizophrenia and schizoaffective disorder. ⋯ In this large dataset, aripiprazole was associated with improvements in a broad range of symptom domains in the short-term treatment of schizophrenia and schizoaffective disorder.
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Review Meta Analysis Comparative Study
Does randomized evidence support sertraline as first-line antidepressant for adults with acute major depression? A systematic review and meta-analysis.
Preliminary evidence suggested that sertraline might be slightly superior to other antidepressant medications in terms of efficacy. The aim of this study was to carry out a systematic review and meta-analysis to compare sertraline with any other antidepressant in the acute phase treatment of major depression at 8 weeks. ⋯ The results of this review suggest that sertraline may be a candidate as the initial choice of antidepressant for people with major depression.
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Review Meta Analysis Comparative Study
Mirtazapine versus other antidepressants in the acute-phase treatment of adults with major depression: systematic review and meta-analysis.
To conduct a comprehensive, systematic review and meta-analysis of the efficacy and tolerability of mirtazapine over other antidepressants in the acute-phase treatment of major depression. ⋯ Although mirtazapine is likely to have a faster onset of action than SSRIs, no significant differences were observed at the end of 6 to 12 weeks' treatment. Clinicians should focus on other practically relevant considerations to tailor treatment to best fit the needs of individual patients.