Ophthalmology
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Multicenter Study
Periocular and orbital amyloidosis: clinical characteristics, management, and outcome.
To present the clinical features and management outcome in a large series of patients with periocular and orbital amyloidosis. ⋯ Periocular and orbital amyloidosis may present with a wide spectrum of clinical findings and result in significant ocular morbidity. Complete surgical excision is not feasible in many cases, and the goal of treatment is to preserve function and to prevent sight-threatening complications.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Prevalence of myopia at 9 months in infants with high-risk prethreshold retinopathy of prematurity.
To examine the prevalence of myopia and high myopia at 9 months corrected age in premature infants who participated in the multicenter randomized trial of Early Treatment for Retinopathy of Prematurity (ETROP). ⋯ Early treatment at high-risk prethreshold did not place eyes at greater risk of myopia and high myopia than did conventional management of eyes with high-risk prethreshold ROP.
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To evaluate the incidence and extent of visual recovery in patients with giant cell arteritis (GCA) treated with high doses of systemic corticosteroids. ⋯ Visual recovery is uncommon in patients who lose vision from GCA. Recovery in visual acuity is not associated with visual field or color vision improvement in this series. Visual deterioration occurs in approximately 27% of eyes despite high-dose IV methylprednisolone. The greatest risk of visual deterioration is in the first 6 days.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Predictive factors for glaucomatous visual field progression in the Advanced Glaucoma Intervention Study.
To investigate the risk factors associated with visual field (VF) progression in the Advanced Glaucoma Intervention Study (AGIS) with pointwise linear regression (PLR) analysis of serial VFs. ⋯ Both increasing age and greater IOP fluctuation increase the odds of VF progression by 30% (for each 5-year increment in age and 1-mmHg increase in IOP fluctuation). The higher risk conferred by IOP fluctuation was consistently observed in eyes with and without a history of cataract extraction.
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Multicenter Study
The Proview phosphene tonometer fails to measure ocular pressure accurately in clinical practice.
To evaluate the Proview Eye Pressure Monitor as a medical instrument and as a technique for enabling a patient to obtain an accurate measure of his or her intraocular pressure (IOP). ⋯ The Proview instrument and technique were reproducible. However, the Proview tonometer seems not to be reliable as an indicator of IOP. The sensitivity for detecting high IOP was low in this cohort, and the agreement with Goldmann applanation was poor for some individuals. This brings into question the underlying assumption that a force proportional to the IOP generates phosphenes.