Neurosurgery
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A historical account of the "medieval" period of stereotactic brain surgery characterizes it as a time of instrument development, choosing of treatment targets, and close rapport between patients and neurological surgeons. Pioneers had frequent contact with the next tier of investigators. Brain function and instrumentation became better understood, leading to the more recent exponential advancements in the field.
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To evaluate the benefits and adverse effects of bilateral subthalamic nucleus stimulation in the treatment of Parkinson's disease (PD) by systematically reviewing the published literature. ⋯ Bilateral subthalamic nucleus stimulation is effective in the treatment of PD. Further refinements in patient selection and surgical technique may lessen the incidence of complications associated with this procedure.
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Comparative Study Clinical Trial
Long-term reliability of endoscopic third ventriculostomy.
To describe the short-term operative success and the long-term reliability of endoscopic third ventriculostomy (ETV) for treatment of hydrocephalus and to examine the influence of diagnosis, age, and previous shunt history on these outcomes. ⋯ Age was the only factor statistically associated with the long-term reliability of ETV. Patients less than 6 months old had poor reliability.
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Multicenter Study Comparative Study
Safety and feasibility of convection-enhanced delivery of Cotara for the treatment of malignant glioma: initial experience in 51 patients.
We report the safety and feasibility of using convection-enhanced delivery to administer Cotara (Peregrine Pharmaceuticals, Inc., Tustin, CA), a novel radioimmunotherapeutic agent, to patients with malignant glioma. ⋯ The majority of Cotara infusions delivered between 90 and 110% of the prescribed administered activity to the targeted region. This method of administration has an acceptable safety profile compared with literature reports of other therapeutics delivered by convection-enhanced delivery.