Irish journal of medical science
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The Irish people were put on lockdown in mid-March 2020 due to concern of the spread of coronavirus. With these societal changes came a notable reduction in emergency department attendance. Our aim was to analyse emergency urological procedures performed during the COVID-19 era versus the previous year. ⋯ Whilst patients with ureteric colic continue to present, those with acute testis pain requiring exploration attended less frequently, raising the possibility of undiagnosed testicular torsion in the community.
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We wished to pilot a survey of volunteers at the annual Watersports Inclusion Games regarding benefits and barriers to participation. We collaborated with community partners regarding the impact of the event, which invites individuals across physical, sensory, intellectual and learning ability spectrums and those experiencing barriers accessing mainstream sport to participate in watersports. ⋯ Our plot data supports previous evidence of the value of volunteerism in inclusive watersports, for the event and for volunteers. It is the first article on inclusive watersports volunteers in Ireland we are aware of, and the largest cohort of inclusive watersports volunteers surveyed internationally.
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Dietary supplement use has continued to rise. In addition to supplement-drug interactions, it is prudent to consider how dietary supplements may interact with a patient's specific pharmacogenetics. Variations in genes associated with CYP 450 enzymes have evidence of impacting drug metabolism and adverse effects. ⋯ CYP P450 activity is an important consideration for any patient but becomes increasingly critical if patients have certain CYP P450 phenotypes that impact metabolism. These popular supplements have the potential for changes in supplement exposure, and adverse effects based on pharmacogenetic profiles. Furthermore, these sites of metabolism are shared with many medications, setting the stage for possibly more profound interactions between medications and supplements. This paper highlights the mechanisms in which dietary supplements may constitute a risk for patients with certain CYP P450 phenotypes. Further research is needed in the area of dietary supplements and their pharmacogenomic implications.
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Comment Letter Case Reports
Orbital involvement in Waldenstrom macroglobulinaemia: a multidisciplinary approach.