Journal of pediatric ophthalmology and strabismus
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J Pediatr Ophthalmol Strabismus · Jan 2003
Randomized Controlled Trial Comparative Study Clinical TrialComparison of anti-emetic effects of ondansetron and low-dose droperidol in pediatric strabismus surgery.
Strabismus surgery is associated with a high incidence of postoperative nausea and vomiting. A dose of 150 microg/kg(-1) of ondansetron has been found to be effective in reducing nausea and vomiting in pediatric patients. However, droperidol (20 to 75 microg/kg(-1)) has shown variable success with various side effects. This randomized, double-blind, placebo-controlled clinical trial was conducted to evaluate the efficacy and safety of 25 microg/kg(-1) of droperidol and compare it with that of 150 microg/kg(-1) of ondansetron in pediatric strabismus surgery. ⋯ Doses of 25 microg/kg(-1) of droperidol and 150 microg/kg(-1) of ondansetron administered at induction of anesthesia are equally effective in reducing the incidence and severity of postoperative nausea and vomiting in children undergoing strabismus surgery.
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J Pediatr Ophthalmol Strabismus · May 2002
Randomized Controlled Trial Comparative Study Clinical TrialComparative evaluation of diclofenac and dexamethasone following strabismus surgery.
To compare efficacy of topical diclofenac sodium 0.1% with dexamethasone 0.1% following strabismus surgery. ⋯ The results of this study suggest that diclofenac may be used as an alternative to dexamethasone after strabismus surgery.
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J Pediatr Ophthalmol Strabismus · Jan 2000
Randomized Controlled Trial Comparative Study Clinical TrialCombination cyclopentolate and phenylephrine for mydriasis in premature infants with heavily pigmented irides.
This study examined whether safe and effective mydriasis can be achieved in premature infants with heavily pigmented irides using combination cyclopentolate 0.2% and phenylephrine 1% eyedrops. ⋯ The single combination eyedrop of cyclopentolate 0.2% and phenylephrine 1% is as effective and safe a mydriatic for infants with dark irides as both tropicamide 0.5% and phenylephrine 2.5%.
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J Pediatr Ophthalmol Strabismus · Sep 1998
Randomized Controlled Trial Comparative Study Clinical TrialA comparison of prophylactic ondansetron hydrochloride and droperidol for strabismus repair in adults.
Prophylactic administration of an antiemetic is a common procedure for patients undergoing strabismus surgery. Droperidol and ondansetron hydrochloride are commonly used antiemetics. This study compared the rates of postoperative nausea and vomiting (PONV) in adult patients undergoing strabismus surgery with prophylactically administered Droperidol or ondansetron hydrochloride. ⋯ No real differences in the ability to prevent PONV between the two medications were found in this study.
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J Pediatr Ophthalmol Strabismus · May 1992
Randomized Controlled Trial Comparative Study Clinical TrialA mydriatic eye-drop combination without systemic effects for premature infants: a prospective double-blind study.
Eye drops used for diagnostic mydriasis may produce systemic side effects in preterm infants. Studies on the pupil dilating and systemic effect of various mydriatic agents yielded conflicting results. We conducted a prospective randomized double-blind study on the systemic effect of two mydriatic eye-drop combinations. ⋯ A significant increase of BP and HR peak values was observed within 7 to 10 minutes after the cyclopentolate/tropicamide combination only. On the other hand, the mydriatic effect of the phenylephrine/tropicamide combination was significantly superior to that of the cyclopentolate/tropicamide combination. We recommend the combination of 2.5% phenylephrine and 0.5% tropicamide to achieve a sufficient diagnostic mydriasis without systemic side effects in preterm infants.