Digestive diseases and sciences
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Pain is common in patients with liver disease, difficult to treat, and poorly understood. ⋯ This large cohort study demonstrates the high prevalence of pain and opioid use in chronic liver disease. While disease variables contribute to pain, psychological symptoms were most strongly associated with pain and opioid use, providing rationale and target for therapeutic interventions.
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We have previously reported that bee venom (BV) has a protective role against acute pancreatitis (AP). However, the effects of apamin, the major compound of BV, on AP have not been determined. The aim of this study was to evaluate the effects of apamin on cerulein-induced AP. ⋯ These results could suggest that apamin could protect against AP by inhibition of JNK activation.
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Both ulcerative colitis (UC) and diarrhea-predominant irritable bowel syndrome (IBS-D) are associated with alterations in enteric serotonin (5-HT) signaling. ⋯ Overexpression of S100A10 in the rectum may play a role in IBS as it is involved in modulating 5-HT1B receptors. The IL10-819 CC is a candidate genotype for both IBS and UC in Japanese.
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Randomized Controlled Trial
Influence of intraluminal acidification on esophageal secondary peristalsis in humans.
Secondary peristalsis contributes to clearance of retained refluxate or material from the esophagus. ⋯ Our data show that acute esophageal acid infusion enhances sensitivity of distension-induced secondary peristalsis and enhances secondary peristaltic activity. The study supports the evidence of the presence of acid-sensitive afferents in the modulation of distension-induced secondary peristalsis in humans.
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Effective and safe sedation for patients with liver cirrhosis is problematic. ⋯ Low-dose propofol sedation provided safe and effective sedation for EGD in cirrhotic patients with rapid recovery.