Digestive diseases and sciences
The most recent articles from:
Dig. Dis. Sci.
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Randomized Controlled Trial Multicenter Study
Efficacy and safety of lubiprostone in patients with chronic constipation.
The aim of this study is to assess the efficacy and safety of lubiprostone in adults with chronic constipation. ⋯ In patients with chronic constipation, lubiprostone produced a bowel movement in the majority of individuals within 24 h of initial dosing, with sustained improvement in frequency as well as other constipation symptoms over 4 weeks of treatment.
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Randomized Controlled Trial Multicenter Study Comparative Study
Antidepressant therapy (imipramine and citalopram) for irritable bowel syndrome: a double-blind, randomized, placebo-controlled trial.
The efficacy of antidepressants in irritable bowel syndrome (IBS) is controversial. No trials have directly compared a tricyclic with a selective serotonin reuptake inhibitor. Our aim was to determine whether imipramine and citalopram are efficacious in IBS. ⋯ Neither imipramine nor citalopram significantly improved global IBS endpoints over placebo.