Neurological research
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Neurological research · Apr 2011
Admission pulse pressure and short-term clinical outcome in patients with intracerebral and subarachnoid hemorrhage in Inner Mongolia, China.
There are currently no data on the comparison of relationship of admission pulse pressure (PP) level with short-term clinical outcome between patients with acute intracerebral hemorrhage and subarachnoid hemorrhage in the Chinese population. We studied the association between admission PP and in-hospital death or dependency in patients with acute intracerebral hemorrhage and subarachnoid hemorrhage in Inner Mongolia, China. ⋯ Increased PP was significantly and positively associated with poor short-term clinical outcome among patients with acute intracerebral hemorrhage, but not acute subarachnoid hemorrhage, in Inner Mongolia, China.
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Neurological research · Mar 2011
Endothelin and the neurovascular unit in pediatric traumatic brain injury.
This study characterized the association between endothelin-1, cerebral hemodynamics, and histopathology after fluid percussion brain injury in the newborn pig. ⋯ These data indicate that fluid percussion injury-induced changes in cerebral hemodynamics are associated with neuronal damage and that endothelin-1 contributes to fluid percussion injury-induced histopathologic changes.
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Neurological research · Mar 2011
Case Reports Clinical TrialPreliminary experience with the use of self-expanding stent as a thrombectomy device in ischemic stroke.
Stent-based techniques may allow rapid arterial recanalization in acute stroke. We present our experience using a self-expanding stent to achieve a transient bypass, and then as a thrombectomy device, with no permanent stent implantation, in acute stroke. ⋯ The presented approach allowed three desired effects: rapid endovascular revascularization, clot removal, and no need of leaving a permanent implant. In our preliminary experience this simple and rapid stent-based mechanical thrombectomy technique has had an unprecedented success rate.
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Neurological research · Mar 2011
Comparative StudyEndothelin-1 is upregulated after traumatic brain injury: a cross-species, cross-model analysis.
This work was designed to compare levels of endothelin-1 following brain injury in both rat and porcine models of head injury. In a broader sense, this work also determines the feasibility of testing traumatic brain injury-related phenomenology across species and models. ⋯ These results show that endothelin-1 peptide concentration elevation is a consistent finding between rat and pig and between weight acceleration and fluid percussion models of traumatic brain injury. This suggests that endothelin-1 elevation is not only a conserved phenomenon in different models of traumatic brain injury, but that it is a likely target for understanding the observed enhanced vascular response to traumatic brain injury and ultimately developing strategies to improve outcome following traumatic brain injury.
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Neurological research · Mar 2011
Endothelin receptor A antagonism reduces the extent of diffuse axonal injury in a rodent model of traumatic brain injury.
While endothelin-1 and its receptors have traditionally been associated with mediating vasoreactivity, we have recently shown that the vast majority of endothelin receptor A expression following traumatic brain injury is localized within the neuron. While it has been suggested that endothelin receptor A plays a role in influencing neuronal integrity, the significance of neuronally expressed endothelin receptor A remains unclear. One report suggests that endothelin-1 signaling mediates diffuse axonal injury. Therefore, this work sought to determine whether treatment with BQ-123, a selective endothelin receptor A antagonist, diminishes the extent of diffuse axonal injury following trauma. ⋯ The results show that endothelin receptor A antagonism reduced the extent of diffuse axonal injury, demonstrating a potential influence of the endothelin system on the intra-axonal cascade of molecular events underlying diffuse axonal injury.