Journal of the American Academy of Dermatology
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J. Am. Acad. Dermatol. · Jun 2001
Randomized Controlled Trial Clinical TrialA randomized trial of the Hawaii SunSmart program's impact on outdoor recreation staff.
Skin cancer is the most common form of cancer in the United States and one of the most preventable. Prevention programs for children at outdoor recreation sites may influence not only the youth, but the staff, or caregivers, as well. By teaching children about sun protection, staff may also change their sun protection behaviors. ⋯ Changes in staff behavior and attitudes are important for their own health, as positive role models, and for the dissemination of skin cancer control programs.
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J. Am. Acad. Dermatol. · May 2001
Randomized Controlled Trial Multicenter Study Clinical TrialImiquimod 5% cream in the treatment of superficial basal cell carcinoma: results of a multicenter 6-week dose-response trial.
Superficial basal cell carcinoma (sBCC) is an increasingly common tumor in fair-skinned populations throughout the world. Imiquimod, an immune response modifier that induces cytokines including interferons, has been shown in preliminary studies to have an effect when applied topically to BCC. ⋯ Imiquimod 5% cream appears to have potential as a patient-administered treatment option in sBCC.
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J. Am. Acad. Dermatol. · Mar 2000
Randomized Controlled Trial Multicenter Study Clinical TrialThe combination of 2% 4-hydroxyanisole (Mequinol) and 0.01% tretinoin is effective in improving the appearance of solar lentigines and related hyperpigmented lesions in two double-blind multicenter clinical studies.
Solar lentigines are a chronic condition of the aging population resulting from years of cumulative sun exposure. A topical treatment that is both safe and effective would be welcome and useful. Combinations of therapeutic agents are often used and allow synergy of mechanisms with tolerability. A tyrosinase inhibitor in use in Europe, 4-hydroxyanisole (Mequinol), and the retinoid tretinoin have been used singly as depigmenting agents. ⋯ For the treatment of solar lentigines and related hyperpigmented lesions, the topical combination product containing 2% 4HA/0.01% tretinoin solution is well tolerated and superior to either active component.
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J. Am. Acad. Dermatol. · Dec 1999
Randomized Controlled Trial Multicenter Study Clinical Trial Controlled Clinical TrialA double-blind, placebo-controlled study of topical tetracaine in the treatment of herpes labialis.
Before the September 1996 approval of 1% penciclovir cream for the treatment of herpes labialis, no other prescription topical therapy was approved for the treatment of this recurrent viral disease affecting approximately 20% of the adult population of the United States. Local anesthetics, such as tetracaine, have been used in over-the-counter topical products, but are only labeled for the relief of pain and itching associated with cold sores and fever blisters. ⋯ Our findings indicate that a 1.8% topical tetracaine cream, when applied frequently, significantly reduces the healing time of recurrent herpes labialis lesions. Additionally, it is perceived by the study subjects to reduce itching of the lesions and to have a beneficial overall effect.
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J. Am. Acad. Dermatol. · Feb 1999
Randomized Controlled Trial Clinical TrialEMLA cream as a topical anesthetic for the repeated mechanical debridement of venous leg ulcers: a double-blind, placebo-controlled study.
A granulating surface is important for skin grafting and healing of leg ulcers. Mechanical debridement to remove necrotic tissue often must be stopped before completion because of pain. ⋯ EMLA produces effective pain relief for the debridement of leg ulcers and shortens the time to a clean ulcer.