Journal of the American Academy of Dermatology
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J. Am. Acad. Dermatol. · Nov 1997
Randomized Controlled Trial Clinical TrialUse of eutectic mixture of local anesthetics: an effective topical anesthetic for slit-smear testing of patients with Hansen's disease.
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J. Am. Acad. Dermatol. · Sep 1997
Randomized Controlled Trial Clinical TrialPrilocaine/lidocaine patch as a local premedication for skin biopsy in children.
Prilocaine-lidocaine emulsion (EMLA) has been used successfully as a local anesthetic in patients undergoing superficial procedures. ⋯ The anesthetic patch reduced the pain experienced by children subjected to a skin biopsy procedure.
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J. Am. Acad. Dermatol. · Jul 1997
Randomized Controlled Trial Clinical TrialThe use of EMLA cream and 1% lidocaine infiltration in men for relief of pain associated with the removal of genital warts by cryotherapy.
Surgical procedures used to remove genital warts (cryotherapy, electrodesiccation) are painful. Attempts to reduce the discomfort of surgery by prior lidocaine infiltration anesthesia are compromised by the pain of the infiltration. ⋯ The application of lidocaine/prilocaine cream as an adjunct to lidocaine infiltration reduced the pain of infiltration and the pain associated with cryotherapy for the removal of genital warts.
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J. Am. Acad. Dermatol. · Sep 1996
Randomized Controlled Trial Clinical TrialEutectic lidocaine/prilocaine 5% cream and patch may provide satisfactory analgesia for excisional biopsy or curettage with electrosurgery of cutaneous lesions. A randomized, controlled, parallel group study.
Needle puncture and infiltrational anesthesia is generally required for minor cutaneous surgical procedures and may be associated with anxiety, fear, discomfort, and pain. The use of topical anesthetics such as eutectic lidocaine/prilocaine 5% cream may provide an alternative means of delivering anesthesia. ⋯ For minor skin surgical procedures involving excisional biopsy or curettage with electrosurgery, eutectic lidocaine/prilocaine 5% cream/Tegaderm and patch formulations were equally effective and provided effective anesthesia in 87% of subjects. The patch formulation may be more convenient for self-application.
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J. Am. Acad. Dermatol. · Oct 1994
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialRelief of pruritus in patients with atopic dermatitis after treatment with topical doxepin cream. The Doxepin Study Group.
Atopic dermatitis is associated with severe pruritus for which effective topical treatment is lacking. As a potent H1 and H2 antagonist, the antipruritic effect of topical doxepin was first demonstrated in histamine-induced itch in nonatopic volunteers. ⋯ Topical doxepin is effective in reducing pruritus in patients with atopic dermatitis. It has an apparent short-term low risk of major side effects or sensitization.