Journal of the American Academy of Dermatology
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J. Am. Acad. Dermatol. · Mar 1994
Randomized Controlled Trial Clinical TrialA controlled clinical trial of topical silicone gel sheeting in the treatment of hypertrophic scars and keloids.
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J. Am. Acad. Dermatol. · Jan 1994
Randomized Controlled Trial Comparative Study Clinical TrialTopical tretinoin (retinoic acid) treatment of hyperpigmented lesions associated with photoaging in Chinese and Japanese patients: a vehicle-controlled trial.
Hyperpigmented lesions are a predominant component of photoaging in Chinese and Japanese persons. Topical 0.1% tretinoin cream improves the hyperpigmentation associated with photoaging in Caucasian persons. ⋯ By clinical, colorimetric, and histologic evaluation, 0.1% tretinoin cream significantly lightens the hyperpigmentation of photoaging in Chinese and Japanese patients.
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J. Am. Acad. Dermatol. · Nov 1991
Randomized Controlled Trial Clinical TrialEpilation of upper lip hirsutism with a eutectic mixture of lidocaine and prilocaine used as a topical anesthetic.
Twenty-one patients were included in a double-blind, placebo-controlled, cross-over study with a eutectic mixture of lidocaine and prilocaine (EMLA). EMLA or placebo was placed on the upper lip for 1 hour; diathermy was then performed for 10 minutes. ⋯ Eighteen of 20 patients preferred EMLA (p less than 0.0001). Local reactions were few and mild.
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J. Am. Acad. Dermatol. · Oct 1990
Randomized Controlled Trial Clinical TrialTreatment of molluscum contagiosum using a lidocaine/prilocaine cream (EMLA) for analgesia.
Eighty-three 4- to 12-year-old children, scheduled for curettage of at least five molluscum contagiosum lesions, participated in a double-blind study. The children were randomly allocated to receive lidocaine/prilocaine (EMLA) cream (n = 58) or placebo cream (n = 25), applied 15, 30, or 60 minutes before treatment. The pain was assessed by the children and the physician as none, slight, moderate, or severe. ⋯ In the placebo group, only one of 24 children (4%) reported no pain. Transient local redness was the only skin reaction noted. In conclusion, an application time of EMLA cream of less than 60 minutes is satisfactory for the curettage of molluscum contagiosum in children.
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J. Am. Acad. Dermatol. · Mar 1987
Randomized Controlled Trial Comparative Study Clinical TrialSafety and efficacy of topical minoxidil in the management of androgenetic alopecia.
Of 149 subjects with androgenetic alopecia, 102 completed 1 year of a double-blind, randomized study comparing 2% minoxidil and 3% minoxidil solutions for safety and efficacy. One third of the subjects used a vehicle placebo for the first 4 months and then switched to 3% minoxidil. At 12 months the 2% minoxidil group switched to a 3% solution. ⋯ Two instances of allergic contact dermatitis and four of pruritus were attributed to use of the drug. Two individuals complained of impotence, which disappeared within a few days of discontinuation of topical minoxidil. This effect has not been reported during the use of minoxidil in its oral form (Loniten) for the treatment of hypertension.(ABSTRACT TRUNCATED AT 250 WORDS)