Journal of the American Academy of Dermatology
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J. Am. Acad. Dermatol. · Oct 2010
Review Meta AnalysisSilver treatments and silver-impregnated dressings for the healing of leg wounds and ulcers: a systematic review and meta-analysis.
Previous systematic reviews of silver-impregnated dressings have been contradictory regarding the healing of leg wounds/ulcers. Our systematic review was restricted to randomized controlled trials. Cochrane Library, Scopus, and MEDLINE databases were searched using the term "silver" in combination with "wound" or "ulcer" (and plural versions) without date/language restriction. ⋯ Meta-analyses found strong evidence for wound healing based on wound size reduction but no evidence based on complete wound-healing or healing rates. Although our results provide some evidence that silver-impregnated dressings improve the short-term healing of wounds and ulcers, long-term effects remain unclear. Clinical trial data with longer follow-up times are needed to address these issues.
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J. Am. Acad. Dermatol. · Aug 2007
Meta AnalysisA meta-analysis to assess the efficacy of oral antiviral treatment to prevent genital herpes outbreaks.
Efficacy of oral antiviral therapies, ie, acyclovir, valacyclovir (VACV), and famciclovir, for suppression of recurrent genital herpes was studied at different doses and regimens. ⋯ The results of this first meta-analysis confirmed the high clinical efficacy of oral acyclovir, VACV, or famciclovir for prophylaxis against recurrent genital herpes.