Methods and findings in experimental and clinical pharmacology
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Methods Find Exp Clin Pharmacol · Apr 1996
Randomized Controlled Trial Comparative Study Clinical TrialRespiratory and analgesic effects of meperidine and tramadol in patients undergoing orthopedic surgery.
The respiratory and analgesic effects of i.v. meperidine, tramadol and their correlation with plasma concentrations of meperidine, tramadol and O-demethyltramadol were determined. Forty-eight patients after total hip or knee replacement were randomly distributed into 3 groups (n = 16 each). At the time of analgesia request, they received in a double-blind manner, i.v. single doses of 100 mg meperidine, 100 mg tramadol, or saline. ⋯ A negative correlation (r = -0.99) between analgesia and tramadol concentrations and a poor positive correlation (r = +0.54) with O-demethyltramadol (a metabolite of tramadol) was observed. Pain intensity differences correlated negatively with meperidine plasma concentrations during the first 30 min (r = -0.97) and positively thereafter (r = +0.92). In the present study, meperidine and tramadol produced comparable analgesia, with a different time course profile, but meperidine induced sedation and respiratory depression while tramadol did not.
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Methods Find Exp Clin Pharmacol · Sep 1993
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialEfficacy of two different intramuscular doses of dipyrone in acute renal colic. Cooperative Study Group.
A randomized multicenter clinical trial was designed to compare the efficacy and tolerance of two different intramuscular doses of dipyrone (1 g and 2 g) with those of the reference drug, diclofenac sodium (75 mg), in the treatment of acute renal colic. A total of 129 patients were included; 43 patients were alloted to receive dipyrone 1 g, 45 to dipyrone 2 g, and 41 to diclofenac. ⋯ There were no significant differences between the three groups in terms of pain relief in the first 60 min, but dipyrone 2 g provided significantly more pain relief than diclofenac and dipyrone 1 g from 60 min to 6 h after drug injection. It is concluded that dipyrone 2 g produced a longer lasting analgesic response than dipyrone 1 g in the treatment of renal colic.