Annals of emergency medicine
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Glyburide, a second-generation sulfonylurea hypoglycemic agent, is metabolized by the P-450 hepatic enzyme system. Ciprofloxacin, a widely used quinolone antibiotic, is a recognized P-450 enzyme inhibitor. ⋯ We present a case of hypoglycemia and an elevated serum glyburide level after 1 week of ciprofloxacin use in a patient receiving long-term glyburide therapy. Clinicians should consider this potential interaction in patients taking glyburide who require antibiotic therapy.
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[American College of Emergency Physicians. Domestic violence: the role of EMS personnel. Ann Emerg Med. August 2000;36:180.].
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[Sklar DP. Letting go. Ann Emerg Med. August 2000;36:167-168.].