Annals of emergency medicine
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Randomized Controlled Trial Comparative Study Clinical Trial
Prochlorperazine versus promethazine for uncomplicated nausea and vomiting in the emergency department: a randomized, double-blind clinical trial.
Nausea and vomiting related to gastritis or gastroenteritis are common complaints in the emergency department. The most effective antiemetic agent is yet undetermined. This study was conducted to compare the efficacy of prochlorperazine versus promethazine for uncomplicated nausea and vomiting in the ED. ⋯ Prochlorperazine works significantly better than promethazine for relieving symptoms of nausea and vomiting more quickly and completely in ED patients with uncomplicated nausea and vomiting.
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[American College of Emergency Physicians. Child abuse. Ann Emerg Med. August 2000;36:180.].
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Comparative Study Clinical Trial
Serum progesterone testing to predict ectopic pregnancy in symptomatic first-trimester patients.
This study was conducted to prospectively measure the accuracy of serum progesterone levels to detect ectopic pregnancy. ⋯ Given similar disease prevalence, roughly one fourth (178/716) of symptomatic patients can be classified as low risk (0%, 95% confidence interval 0 to 2%) for having an ectopic pregnancy using a progesterone cutoff of 22 ng/mL. Whether implementation of rapid progesterone testing can safely expedite care and reduce the need for urgent diagnostic evaluation or admission remains to be determined.