Annals of emergency medicine
The most recent articles from:
Ann Emerg Med
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Multicenter Study Clinical Trial
Acetaminophen overdose: a 48-hour intravenous N-acetylcysteine treatment protocol.
To determine the safety and efficacy of a 48-hour IV N-acetylcysteine (IV NAC) treatment protocol for acute acetaminophen overdose. ⋯ This 48-hour IV NAC protocol is safe and effective antidotal therapy for acetaminophen overdose. Based on available data, it is equal to 72-hour oral and 20-hour IV treatment protocols when started early and superior to the 20-hour IV regimen when treatment is delayed. Further study will be required to determine its relative efficacy in the high-risk patient treated very late.