European heart journal
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European heart journal · Oct 2013
The impact of susceptibility loci for coronary artery disease on other vascular domains and recurrence risk.
Genome-wide association studies (GWAS) have identified many genetic loci related to coronary artery disease (CAD) and myocardial infarction (MI). However, the extent to which these loci are related to other vascular diseases is not clear. The aim of this study is to investigate the cumulative effects of risk alleles associated with CAD/MI on ischaemic stroke (IS), abdominal aortic aneurysm (AAA), and peripheral artery disease (PAD). ⋯ These findings suggest that CAD/MI-associated risk alleles play an aetiological role in different types of atherosclerotic disease.