Scandinavian journal of rheumatology
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Scand. J. Rheumatol. · Jan 2001
Randomized Controlled Trial Comparative Study Clinical TrialCelecoxib versus diclofenac in the management of osteoarthritis of the knee.
A clinical trial was conducted in 600 patients with OA of the knee to test the hypothesis that the specific COX-2 inhibitor, celecoxib, has equivalent efficacy and a superior tolerability/safety profile when compared to diclofenac, the current worldwide standard of care. ⋯ Celecoxib 200 mg daily is as effective as diclofenac 150 mg daily for relieving signs and symptoms of OA of the knee, including pain, and has a rapid onset of action. However, celecoxib appears to have a superior safety and tolerability profile.
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Scand. J. Rheumatol. · Jan 1997
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialLocal NSAID gel (eltenac) in the treatment of osteoarthritis of the knee. A double blind study comparing eltenac with oral diclofenac and placebo gel.
In a randomized, double blind, multicentre study with 4 weeks follow-up of 290 patients with osteoarthritis of the knee joint, a topical NSAID (eltenac) was compared with oral diclofenac and placebo. The main outcome, Lequesne's Index and pain by VAS showed no statistically significant differences between neither of the active treatments and placebo for the total study population. ⋯ Local skin reactions were twice as frequent in the eltenac than in the placebo group. Taking into account the nature of the treatment for a chronic disease like OA, our results indicate that eltenac gel could be a safe alternative to oral NSAIDs.
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Scand. J. Rheumatol. · Jan 1996
Randomized Controlled Trial Clinical TrialQuantitative and qualitative assessments of pain in children with juvenile chronic arthritis based on the Norwegian version of the Pediatric Pain Questionnaire.
Quantitative and qualitative aspects of pain were studied using a standardized questionnaire (the Varni/Thompson Pediatric Pain Questionnaire--PPQ). Fifty-seven of 64 consecutive in- and out-patients (6-18 yrs) with juvenile chronic arthritis (pauciart. n = 27, polyart. n = 30) and 52 parents participated. The patients were examined by the same rheumatologist and randomly interviewed by either a disabled or a non-disabled person. ⋯ Forty-two percent of the patients thought it valuable to be interviewed by a disabled physician. The Norwegian Varni/Thompson PPQ is easy to administer to children down to six years and makes it possible to compare results internationally. Lack of agreement on the assessment of pain by a child and his/her parent indicates the need to interview both parties.
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Scand. J. Rheumatol. · Jan 1995
Randomized Controlled Trial Clinical TrialPain analysis in patients with fibromyalgia. Effects of intravenous morphine, lidocaine, and ketamine.
Pain intensity, muscle strength, static muscle endurance, pressure pain threshold, and pain tolerance at tender points and control points were assessed in 31 patients with fibromyalgia (FM), before and after intravenous administration of morphine (9 patients), lidocaine (11 patients), and ketamine (11 patients). The three different studies were double-blind and placebo-controlled. The patients were classified as placebo-responders, responders (decrease in pain intensity by > 50%) and non-responders. ⋯ Tenderness at tender points decreased and endurance increased significantly, while muscle strength remained unchanged. The present results support the hypothesis that the NMDA receptors are involved in pain mechanisms in fibromyalgia. These findings also suggest that central sensitization is present in FM and that tender points represent secondary hyperalgesia.
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Scand. J. Rheumatol. · Jan 1986
Randomized Controlled Trial Comparative Study Clinical Trial Controlled Clinical TrialDiclofenac versus lidocaine as injection therapy in myofascial pain.
Twenty-four patients with localized myofascial pain were treated with injections, 11 with 2 ml lidocaine 1% and 13 with 2 ml diclofenac (Voltaren) (50 mg) given in the trigger-point. The effect of therapy was measured by visual analogue scale (VAS) during 5 h corresponding to the expected pharmacological period of effect. ⋯ Compared with the pain score value at the start the treatment with diclofenac gave a significant alleviation (p less than 0.05) after 3 h, whereas treatment with lidocaine did not give any significant change in pain level. The demonstrated effect of a prostaglandin synthesis inhibitor illustrates how inflammation is involved as an etiological factor in myofascial pain.