Anticancer research
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Anticancer research · Nov 1999
Early effects of retinoic acid on proliferation, differentiation and apoptosis in non-small cell lung cancer cell lines.
Retinoids represent a potentially useful class of drugs in the chemoprevention and treatment of cancer, due to their ability to regulate cell proliferation and differentiation. However, there is controversy in the literature about the effects of all-trans retinoic acid (ATRA) in non- small cell lung cancer (NSCLC). In this study we examined the effects of ATRA on apoptotic death in NSCLC. ⋯ These results indicate the possibility of the early growth-inhibitory and apoptotic effects of ATRA in NSCLC which may result in selection of ATRA-resistant cells.
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Anticancer research · Nov 1999
Cytotoxicity of L-cycloserine against human neuroblastoma and medulloblastoma cells is associated with the suppression of ganglioside expression.
Human neuroblastoma and medulloblastoma express abnormal ganglioside patterns especially GD2 and GM2 which are important for tumour growth. We tested the effects of L-cycloserine (L-CS), a potent inhibitor of synthesis of glycosphingolipids, on the growth, viability and expression of GD2 and GM2 in neuroblastoma and medulloblastoma cells. ⋯ L-CS is a selective antitumoral agent for neuroblastoma and medulloblastoma cells with the ability to reduce expression of tumour associated gangliosides. In vivo experiments suggest that L-CS may be effective drug for treatment of neuroblastoma and medulloblastoma.
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Anticancer research · Sep 1999
Concurrent chemoradiotherapy for locally advanced esophageal cancer--a pilot study by using daily low-dose cisplatin and continuous infusion of 5-fluorouracil.
Concurrent chemoradiotherapy (CCRT) has recently become a promising treatment for esophageal cancer. However, most investigators have adopted the conventional or modified Wayne-State PF (cisplatin plus 5-fluorouracil) regimen, which is inevitably associated with moderate to severe treatment-related toxicities. In this pilot study, we incorporated a daily low-dose regimen of cisplatin and 5-fluorouracil into CCRT in order to improve the compliance of the patients. ⋯ We suggest that for locally advanced esophageal cancer CCRT with the aforementioned daily low-dose regimen, is a treatment with good patient compliance.
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Anticancer research · Sep 1999
Tumor blood flow modifying effect of electrochemotherapy with bleomycin.
Electrochemotherapy combines administration of the chemotherapeutic drug, followed by application of electric pulses in order to increase drug delivery into the cells. The aim of this study was to determine the tumor blood flow modifying effect of electrochemotherapy with bleomycin and correlate it with its antitumor effectiveness and extent of tumor necrosis. ⋯ The results indicate that Patent blue staining technique is a simple and reliable method for estimation of tumor blood flow and that antitumor effectiveness of electrochemotherapy with bleomycin could be partly attributed to its tumor blood modifying and anti-vascular effect.
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Anticancer research · Jul 1999
ReviewRadiotherapy in the symptomatic treatment of the oncological patients.
This paper presents an overview on the palliative use of radiotherapy in the treatment of cancer patients. The aim of symptomatic treatment is to improve the patient's quality of life through the control of local symptoms, without serious disturbance of the life style. Radiotherapy can control many symptoms like metastasis bone pain hematological disorders and other.