Rheumatology international
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Fatigue is a frequent symptom during ankylosing spondylitis (AS) often under estimated which needs to be measured properly with respect to its intensity by appropriate measures, such as the multidimensional assessment of fatigue (MAF). The aims of this study were to translate into the classic Arabic version of the MAF questionnaire and to validate its use for assessing fatigue in Moroccan patients with AS. The MAF contains 16 items with a global fatigue index (IGF). ⋯ The construct validity showed a positive correlation between MAF and the axial (r = 0.34) and peripheral (r = 0.32) visual analogical scale, the Bath ankylosing spondylitis disease activity index (BASDAI) (r = 0.77), the first item of BASDAI (r = 0.85), the functional disability by the Bath ankylosing spondylitis functional index (r = 0.64), the erythrocyte sedimentation rate (r = 0.43) and the C reactive protein (r = 0.30) (for all P < 0.001). There was no statistical correlation between MAF and the other variables. The Arabic version of the MAF has good comprehensibility, internal consistency, reliability and validity for the evaluation of Arabic speaking patients with AS.
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Hoarseness due to left recurrent laryngeal nerve paralysis (LRLN) caused by identifiable cardiovascular disease is described as Ortner's syndrome or cardiovocal syndrome. This was first reported by Ortner in 1897 to describe left recurrent laryngeal nerve palsy secondary to mitral stenosis. This case report describe a patient with giant cell arteritis with initial presentation of Ortner's syndrome.
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Personality may play an important role in the development and initiation of fibromyalgia (FM). It may also be used for individualized treatment planning. We aimed to assess personality profiles of FM patients and to evaluate the association of personality profiles with education, symptom severity, depression, anxiety, and functioning. ⋯ A negative correlation has been found between SD scores and depression scores. The study suggests that FM patients have distinctive temperament and character profile compared with healthy controls. FM patients tend to have high HA, high ST, and low SD scores.
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Helper T (Th) cells comprising Th1, Th2, Th17, and Treg are involved in the pathogenesis of various vascular inflammations, and information about Th cells in Henoch-Schonlein purpura (HSP) is still controversial. The aim of our study was to investigate the changes in CD4(+) T cell subsets and their roles in the pathogenesis of HSP. Thirty children with diagnosis of HSP and thirty age-matched healthy controls were enrolled in this study. ⋯ Plasma concentrations of IL-17A, IL-4, and IL-6 in patients with HSP were found to be much higher than those of the control group (P < 0.05), and no differences between IFN-γ, IL-12, and TGF-β were detected between the two groups (P > 0.05). Presence of higher proportions of Th2 and Th17 cells in patients with HSP could be closely correlated with aberrant creation of antibody and development of vessel vasculitis. The changes in cytokine milieu in peripheral blood may play an important role in the derangement of CD4(+) T cell subset.
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This study was conducted to estimate the point prevalence of chronic widespread pain (CWP) and fibromyalgia syndrome (FMS) in a primary care center of a hospital in Korea. CWP was defined as pain lasting more than 3 months involving all the classified pain sites (axial, left and right, above and below waist). FMS was diagnosed by the American College of Rheumatology (ACR) criteria and also by clinical judgment of a physician. ⋯ When compared to NCP, CWP was significantly associated with the female gender after adjusting for other variables (odds ratio 4.2; 95% CI 1.4-12.4, P = 0.009). Compared to NCP, CWP patients had lower levels of education (P = 0.018), a lower likelihood of a professional occupation (P = 0.014), infrequent alcohol intake (P = 0.014) and a lower proportion of current smokers (P = 0.003) based on a univariable analysis. In this Korean hospital-based study, CWP patients were common and had different demographic characteristics and life habits from NCP.