Journal of pediatric gastroenterology and nutrition
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J. Pediatr. Gastroenterol. Nutr. · Feb 2013
Drug utilization and off-label drug use in Spanish pediatric gastroenterology outpatients.
The clinical use of medicines outside the conditions authorized in their Summary of Product Characteristics (SPC) (off-label use) is a common practice in pediatrics. The aim of the present study was to describe and quantify the medicines received by children attended in the pediatric gastroenterology department, their off-label use, and compliance with accepted rules for said use. ⋯ The study found a high percentage of off-label use of medicines in the Pediatric Gastroenterology outpatient setting, especially in children younger than 2 years. Several initiatives were derived from the present study and implemented in our hospital.
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J. Pediatr. Gastroenterol. Nutr. · Feb 2013
Methods and effects of a case-based pediatric gastroenterology online curriculum.
Asynchronous learning, using Web-based instruction, is developing a growing role in medical education. Restrictions on resident work hours continue to require restructuring of formal educational activities in many programs. The objectives of this curriculum development project was to determine whether using blended learning with case-based online modules supplemented by faculty-facilitated case discussion was effective and well received. ⋯ This curriculum, which uses online teaching reinforced by faculty-facilitated case discussion, was both effective and well received by learners. The implementation of this curriculum appears to have had sustained beneficial effects on the learning environment beyond the simple acquisition of medical knowledge.
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J. Pediatr. Gastroenterol. Nutr. · Nov 2012
Upper gastrointestinal histopathological findings in children and adolescents with nonulcer dyspepsia with Helicobacter pylori infection.
The aim of the study was to investigate the histopathological lesions in the upper gastrointestinal mucosa associated with Helicobacter pylori infection in children with nonulcer dyspepsia. ⋯ The prevalence of H pylori infection was high among children with dyspepsia and associated with moderate/severe degrees of gastric inflammation. The high scores of esophagitis in the noninfected group point to 2 distinct groups of pathological conditions sharing similar clinical patterns.
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J. Pediatr. Gastroenterol. Nutr. · Nov 2012
Serial evaluation of children with ALF with advanced MRI, serum proinflammatory cytokines, thiamine, and cognition assessment.
This prospective, sequential study was done to understand changes in cerebral edema (CE) on magnetic resonance imaging and magnetic resonance spectroscopy, liver functions, and neurocognitive testing (NCT) in children with acute liver failure (ALF). ⋯ Patients with ALF have CE contributed by raised brain glutamine and PCs. MBs are small because of thiamine deficiency and show recovery in follow-up. CE and brain glutamine recover earlier than normalization of NCT and liver functions. Persistence of raised cytokines up to 6 months after insult suggests possible contribution from liver regeneration.
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J. Pediatr. Gastroenterol. Nutr. · Sep 2012
Randomized Controlled Trial Comparative StudyCan colonic manometry studies be done on the day of colonic motility catheter placement?
Colonic manometry has been used to assess colonic neuromuscular integrity in pediatric patients with severe constipation unresponsive to standard medical therapy and to tailor their treatment plans. There are presently no available standard protocols for conducting colonic manometry studies. The aim of the present study was to determine whether colonic manometry studies can be conducted on the same day the colonic motility catheters are placed and to compare the effects of inhaled sevoflurane versus intravenous propofol, used during catheter placement, on colonic motility. ⋯ Colonic manometry studies can be conducted as early as 4 hours following catheter placement with either propofol or sevoflurane used for anesthesia.