Thrombosis research
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Thrombosis research · Jan 2008
Multicenter StudyFactors associated with the timing of diagnosis of venous thromboembolism: results from the MASTER registry.
Signs and symptoms of venous thromboembolism (VTE) are non-specific and thus can make diagnosis difficult, even for an experienced clinician. We aimed to evaluate the timing of diagnosis of deep vein thrombosis (DVT) and pulmonary embolism (PE) in Italian hospitals and to identify individual and clinical predictors of timely or delayed diagnosis. ⋯ Substantial delays occur when diagnosing both DVT and PE. The severity of presentation, but not patient risk profile are associated with earlier diagnosis, even in patients with signs or symptoms of PE.
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Thrombosis research · Jan 2008
ReviewWarfarin-reversal: results of a phase III study with pasteurised, nanofiltrated prothrombin complex concentrate.
Bleeding can be a major problem in patients on oral anticoagulation therapy. Beriplex P/N is a prothrombin complex concentrate (PCC) that has been developed for the rapid reversal of anticoagulation in patients requiring immediate haemostatic control. Beriplex P/N contains high concentrations of the coagulation factors II, VII, IX and X, together with the inhibitors protein C and protein S, and it can be rapidly prepared and administered at an infusion rate of up to 8.0 mL/min. ⋯ There were no adverse events related to the rapid rate of infusion and, of the 8 serious adverse events reported; only 1 was regarded as being possibly related to treatment. No virus transmission was observed and changes in thrombogenicity markers were found to be transient and did not correspond to any clinically observed thromboembolic events. In conclusion, Beriplex P/N is an effective and well-tolerated therapy for rapid, complete and predictable reversal of anticoagulation in patients with acute bleeding or requiring emergency surgery.
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Thrombosis research · Jan 2008
Randomized Controlled TrialImproved fibrinolytic activity during exercise may be an effect of the adipocyte-derived hormones leptin and adiponectin.
Physical activity is associated with improved fibrinolytic activity and reduced risk for cardiovascular disease. High levels of leptin and low levels of adiponectin, both adipocyte-derived hormones, or adipokines, are related to dysfibrinolysis and risk for cardiovascular disease. In this study, we explored if improved fibrinolytic activity during exercise could be linked to changes in leptin and adiponectin levels. ⋯ Heavy exercise induced improved fibrinolytic activity, which was associated independently with changes in circulating levels of the adipocyte-derived hormones leptin and adiponectin. Improved fibrinolytic activity (and reduced risk for cardiovascular disease) related to physical activity could possibly be mediated by leptin and adiponectin.
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Thrombosis research · Jan 2008
Randomized Controlled TrialThe relationship between maintenance dosages of three vitamin K antagonists: acenocoumarol, warfarin and phenprocoumon.
Vitamin K antagonists of the coumarin type are widely used oral anticoagulants. ⋯ We determined the transition factors between warfarin, phenprocoumon and acenocoumarol. With these transition factors physicians are able to estimate the maintenance dose when it is necessary for a patient to switch from one coumarin to the other.
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Thrombosis research · Jan 2008
Hemostatic variation during perioperative period of orthotopic liver transplantation without venovenous bypass.
To measure the variations of different parameters in the hemostatic system and to analyze their roles in the development of hemostatic disorder in patients with orthotopic liver transplantation (OLT) procedures routinely performed without venovenous bypass. ⋯ In the entire process of OLT operation, coagulation defects, hyperfibrinolysis and platelet numbers decrease could develop hemostatic disorder. The data obtained in this study might contribute to a better understanding of the pathophysiology and assessment of bleeding risk in the OLT.