Cornea
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The purposes of this study were to describe the clinical characteristics of corneal patients with mutations in the SLC4A11 gene and to determine if these characteristics could be correlated with specific genetic mutations. ⋯ Corneal endothelial cells are more vulnerable to defects in the functional activity of SLC4A11 than cells of the striae vascularis of the inner ear. Both congenital hereditary endothelial dystrophy 2 and Harboyan syndrome have similar ocular phenotypes, ie, diffuse bilateral corneal edema present at birth or within the neonatal period; hence, audiometry must be performed to differentiate the two conditions.
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To evaluate the visual and refractive outcomes after deep anterior lamellar keratoplasty (DALK) using the big-bubble technique in eyes with keratoconus. ⋯ : DALK using the big-bubble technique appears to be a safe and effective procedure for eyes with moderate to advanced keratoconus. In case of extensive intraoperative DM perforation, it does not pose any limitation to ongoing penetrating keratoplasty.
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The purpose of this study was to investigate risk factors for and results of treatments in patients with traumatic wound dehiscence and lens extrusion after penetrating keratoplasty. ⋯ Patients who undergo penetrating keratoplasty are susceptible to graft wound dehiscence resulting from trauma, especially during the first year after keratoplasty. This type of dehiscence is more prevalent in young people, who engage in more social activities and are more exposed to trauma that may lead to blindness. Patient education about the effects of trauma, use of protective eye shields by patients, and performance of lamellar keratoplasty instead of penetrating keratoplasty can decrease trauma and its effects in these patients.
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To report the outcome of penetrating keratoplasty with small-diameter and glycerin-cryopreserved grafts for eccentric corneal perforation. ⋯ Small-diameter penetrating keratoplasty seems to be effective in treating various eccentric corneal perforations. Glycerin-cryopreserved donors may be a suitable alternative to fresh material for this technique, which solves the problem of shortage in supplying corneas and can be used in an emergency.
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To investigate changes in corneal topography and morphology in human eyes wearing orthokeratology (OK) lenses for overnight and over a 5-year period. ⋯ Short-term and long-term OK lens wear can effectively correct myopia by flattening the cornea. The flattened cornea in the short-term lens wear is mainly because of the thickening of the midperipheral cornea. In the long-term lens wear, however, this change is associated with thickening of the midperipheral cornea and thinning of the central corneal epithelium.