Journal of the American College of Cardiology
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J. Am. Coll. Cardiol. · Oct 2012
Comparative StudyAdolescence risk factors are predictive of coronary artery calcification at middle age: the cardiovascular risk in young Finns study.
The purpose of this study was to examine the roles of adolescence risk factors in predicting coronary artery calcium (CAC). ⋯ Elevated adolescence LDL-C and systolic BP levels are independent predictors of adulthood CAC, indicating that adolescence risk factor levels play an important role in the pathogenesis of coronary heart disease.
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J. Am. Coll. Cardiol. · Oct 2012
Randomized Controlled Trial Multicenter Study Comparative StudyImpact of home versus clinic-based management of chronic heart failure: the WHICH? (Which Heart Failure Intervention Is Most Cost-Effective & Consumer Friendly in Reducing Hospital Care) multicenter, randomized trial.
The goal of this study was to make a head-to-head comparison of 2 common forms of multidisciplinary chronic heart failure (CHF) management. ⋯ HBI was not superior to CBI in reducing all-cause death or hospitalization. However, HBI was associated with significantly lower healthcare costs, attributable to fewer days of hospitalization. (Which Heart failure Intervention is most Cost-effective & consumer friendly in reducing Hospital care [WHICH?]; ACTRN12607000069459).
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J. Am. Coll. Cardiol. · Oct 2012
Galectin-3, a marker of cardiac fibrosis, predicts incident heart failure in the community.
The aim of this study was to examine the relation of galectin-3 (Gal-3), a marker of cardiac fibrosis, with incident heart failure (HF) in the community. ⋯ Higher concentration of Gal-3, a marker of cardiac fibrosis, is associated with increased risk for incident HF and mortality. Future studies evaluating the role of Gal-3 in cardiac remodeling may provide further insights into the role of Gal-3 in the pathophysiology of HF.
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J. Am. Coll. Cardiol. · Oct 2012
Statins, risk of diabetes, and implications on outcomes in the general population.
This study aimed to evaluate the association of statin exposure and incident diabetes, and subsequent outcomes in the general population. ⋯ Risk of diabetes was increased after statins, but outcomes were favorable.